Clinical implications of doubling time of gastrointestinal submucosal tumors

Table 1 Demographic characteristics of all 53 patients

Characteristic	Value
Sex, No.	male/female: 26/27
Age, median (range), yr	63.0 (31-83)
Tumor location, No.	Esophagus/stomach/duodenum: 4/47/2

Table 2 Histopathological diagnosis

	Esophagus (n = 4)	Stomach (n = 47)	Duodenum (n = 2)	Total(n = 53)
GIMT	4	45	0	49
GIST	0	34	0	34
Leiomyoma	2	3	0	5
Schwannoma	1	2	0	3
Spindle-cell tumor	1	6	0	7
Ectopic pancreas	0	1	0	1
Hamartoma	0	0	1	1
Intramural developmental cyst	0	1	0	1
Brunner’s adenoma	0	0	1	1

GIST: Gastrointestinal submucosal tumors.

Table 3 Details of 53 patients

	Resected tumors(n = 34)	Unresected tumors (n = 19)	Total (n = 53)	GIST (n = 34)
Follow-up period, median (range), mo	24.9 (6.6-210)	36.5 (11.2-183.6)	31.7 (6.6-210)	27.3 (6.6-210)
EUS sessions, median (range)	3 (2-8)	4 (2-13)	3 (2-13)	3 (2-11)
Tumor diameter at initial EUS, median (range), mm	19.5 (10-30)	19.0 (11.5-44.8)	19.1 (10-44.8)	19.0 (10.9-44.8)
Tumor diameter before surgery or FNA, median (range), mm	28.0 (20-43.1)	22.8 (15.2-52.1)	25.3 (13.7-52.1)	26.7 (13.7-52.1)
Time from the final EUS to surgery, median (range)	3.8 mo (22d-16.3 mo)	-	-	-

GIST: Gastrointestinal submucosal tumors; EUS: Endoscopic ultrasound; FNA: Fine-needle aspiration.

Table 4 Details of 34 patients with gastrointestinal submucosal tumors

	Extremely low plus low risk (n = 28)	Intermediate risk(n = 3)	High risk (n = 3)	Total (n = 34)
Follow-up period, median (range), mo	31.0 (6.6-210)	47.3 (11.2-49.9)	12.4 (7.4-16.7)	27.3 (6.6-210)
Initial tumor diameter, median (range), mm	18.6 (10.9-30.0)	28.5 (20.0-44.8)	25.5 (14.0-27.3)	19.0 (10.9-44.8)
Doubling time, median (range), mo	24.0 (2.0-183.6)	17.1 (6.1-19.4)	3.9 (0.8-10.4)	17.2 (0.8-183.6)

Risk classification: Based on tumor diameter and mitotic figures.

Table 5 Tumors other than gastrointestinal submucosal tumors

	No. of patient	Follow-up period, median (range), mo	Doubling time, median (range), mo
Leiomyoma	5	47.1 (10.7-137.2)	231.2 (21.3-1303.8)
Schwannoma	3	50.1 (24.3-71.7)	104.7 (3.9-305.4)
Ectopic pancreas	1	66.5	274.9
Hamartoma	1	99.6	61.2
Intramural developmental cyst	1	29.5	49.0
Brunner’s adenoma	1	30.6	134.7

Table 6 Comparison according to diagnosis

	Doubling time (mo), median	P value
GIST vs Leiomyoma + schwannoma	17.2 vs 204.2	0.005
High risk vs Intermediate risk	3.9 vs 17.1	0.127
Intermediate risk vs Extremely low + low risk	17.1 vs 24.0	0.423
High risk vs Extremely low + low risk	3.9 vs 24.0	0.033
High + intermediate risk vs Extremely low + low risk	8.2 vs 24.0	0.047

GIST: Gastrointestinal submucosal tumors.