Attempt to calculate the prevalence and features of chronic hepatitis C infection in Tuscany using administrative data

Table 1 Prevalence of anti-hepatitis C virus and hepatitis C virus-RNA by age in Italy and Tuscany on 01.01.2015

	Italy				Tuscany
	Anti-HCV (%)	HCV-RNA+1 (%)	No. of resident people anti-HCV+	No. of HCV-RNA+	No. of resident people anti-HCV+	No. of HCV-RNA+
Geographic area
North	1.3 (0.8-1.8)	39.1	361397	140945	108827	64317
Center	2.9 (1.7-4.1)	59.1	350628	206871
South	4.6 (3.4-5.8)	56.0	961638	538517
Age
0-23 mo	3.8 (1.0-6.6)	14.3	586772	83912	33962	4862
2-14 yr	0.8 (0.3-1.3)	66.6	547123	364383	31373	20903
15-30 yr	1.8 (1.0-2.6)	44.4	178552	79277	9696	4305
31-45 yr	5.9 (3.8-8.0)	48.3	767082	370500	46649	22532
46-60 yr	6.8 (3.9-9.7)	65.0	911233	592301	56568	36769
> 60 yr	5.2 (1.9-8.5)	66.6	836736	557266	73919	49230
Total	2.7 (2.2-3.2)	52.6	1641482	863419	108827	64317

¹HCV-RNA positive % calculated on anti-HCV;

²Using Istat data, the age range is 0-24 mo;

³Using Istat data, the age range is 3-14 year. The total is not the sum of Cases. Source: Regional Health Agency of Tuscany on Ansaldi et al[6] prevalence and National Institute of Statistic data.

Table 2 Hepatitis C virus genotypes prevalence estimation in Italy and Tuscany

Genotypes	HCV-RNA
	Italy (n = 863419)	Tuscany (n = 64317)
1b	518051	38590
2c	172684	12863
1a	51805	3859
3a	51805	3859
4a/d	69074	5145

Source: Regional Health Agency of Tuscany on Ansaldi et al[6] prevalence and National Institute of Statistic data.

Table 3 Hepatitis C virus - RNA resident population in Tuscany known to the Regional Health System by gender and age group n (%)

Age (yr)	Males	Females	Total
0-14	70 (0.5)	58 (0.5)	128 (0.5)
15-34	633 (4.3)	522 (4.6)	1155 (4.5)
35-44	1862 (12.8)	1104 (9.7)	2966 (11.4)
45-54	5270 (36.1)	2414 (21.3)	7684 (29.6)
55-64	2914 (20.0)	1743 (15.4)	4657 (18.0)
65-74	1920 (13.2)	2325 (20.5)	4245 (16.4)
75+	1918 (13.1)	3165 (27.9)	5083 (19.6)
Total	14587 (100)	11331 (100)	25918 (100)
	56%	44%

Source: Regional Health Agency of Tuscany.

Table 4 Charlson Index score adjusted for age calculated on the estimated resident population in hepatitis C virus - positive patients from Tuscany known to the Regional Health System based on age group

Age (yr)	CHARLSON INDEX
	0	1-2	3-4	≥ 5
0-14	82	45	1	0
15-34	753	373	21	8
35-44	1.790	1.001	79	96
45-54	4.165	2.633	311	575
55-64	2.365	1.566	346	380
65-74	1.947	1.656	397	245
75+	1.850	1.974	885	374
Total	12.952	9.248	2.040	1.678
	50%	36%	8%	6%

Source: Regional Health Agency of Tuscany.

Table 5 Patients known to the Regional Health Agency of Tuscany treated with pegylated interferon + ribavirin and/or direct-acting antiviral drugs

Genotypes	HCV patients treated with PEGINF + Rib	Sustained virological responders to PEGINF + Rib	Elegible patients to DAAs	HCV patients treated with DAAs	Sustained virological responders1 to DAAs
1b (60%)	4516	2075	2445
1a (6%)	452
2c (20%)	1505	1075	364	1996	1896
3a (6%)	452	271	151		(about 95% SVR)
4a/d (8%)	603	247	300
Totale	7528	3668	3260

¹HCV is considered regardless of genotypes. Sustained virological responders and total number of patients based on genotype - Source: Regional Health Agency of Tuscany and prevalence data by Marcellin et al[8]. PEGINF: Pegylated Interferon; RBV: Ribavirin; DAAs: Direct-acting antiviral drugs.