Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis

Table 1 Study details

Ref.	Study design	Location	Practice setting	Study period	Procedure Indication	Number patients	Gender	Age (yr)	Primary outcome	ADR EAC standard	EAC Complications	Cecal intubation rate/time EAC standard
Marsano et al[13] 2014	Retrospective chart review	New York	Academic, community	9/13-11/13	Screening, surveillance	318	NR	NR	ADR	47%	NR	NR/NR
										30%		NR/NR
Biecker et al[14] 2015	Randomized prospective 2-center RCT	Germany	Academic	2/13-8/13	Screening, surveillance, diagnostic	498	249 male (50%)	67 (56-75),	Polyps/procedure	35%	Mucosal injury (9)	98%/NR
							249 female (50%)	Median (IQR)		27%	Loss of cuff (6)	98%/NR
Floer et al[15] 2014	Randomized prospective 4-center RCT	Germany	Academic	2/14-7/14	Screening, surveillance, diagnostic	492	231 male (47%)	64 (54-73),	ADR	35%	Mucosal injury (18)	96%/NR
							261 female (53%)	Median (IQR)		21%		94%/NR
Tsiamoulos et al[16] 2015	Prospective observational single center	United Kingdom	Academic	4/13-9/14	Screening	399	NR	NR	ADR	69%	Elective removal (1)	NR/7.5 min (mean)
										58%	Discomfort (1)	NR/9.5 min (mean)
van Doorn et al[17] 2015	Randomized prospective 5-center RCT	Netherlands	Academic	8/13-10/14	Surveillance, FIT positive, family history, diagnostic	1063	549 Male (51.6%)	65,	Adenomas/patient, ADR	54%	Elective removal (22)	98%/7 min (median)
							514 Female (48.4%)	Median		53%	Post-polypectomy bleeding (2)	99%/8.3 min (median)
											Thromboembolic event (1)
Shah et al[18] 2015	Retrospective chart review	California	Veterans Affair’s Hospital	1/14-2/15	Screening, diagnostic	449	417 male (92.9%)	NR	ADR, SSADR	62%	NR	NR/NR
							32 female (7.1%)			49%		NR/NR
Cattau et al[19] 2015	Prospective randomized multi center RCT	Tennessee	Community	NR	Screening	658	317 male (48.2%)	58 ± 8,	ADR	50%	NR	99%/NR
							341 female (51.8%)	mean ± SD		46%		98%/NR
Grewal et al[20] 2015	Retrospective chart review	California	Academic	8/14-5/15	Screening, surveillance, diagnostic	1237	595 male (48.1%)	61 (54-69)	SSADR	NR	NR	NR/NR
							642 female (51.9%)	Median (IQR)				NR/NR
Chin et al[21] 2015	Retrospective chart review	California	Academic	8/14-5/15	Screening	510	234 male (45.9%)	57 (52-61),	ADR	56%	NR	99%/12 min (mean)
							276 female (54.1%)	Median (IQR)		45%		97%/11 min (mean)

ADR: Adenoma detection rate; EAC: Endocuff assisted colonoscopy; FIT: Fecal immunohistochemical testing; IQR: Interquartile range; NR: Not reported; RCT: Randomized, controlled trial; SSADR: Sessile serrated adenoma detection rate.