Copyright
©The Author(s) 2016.
World J Gastroenterol. Oct 21, 2016; 22(39): 8831-8843
Published online Oct 21, 2016. doi: 10.3748/wjg.v22.i39.8831
Published online Oct 21, 2016. doi: 10.3748/wjg.v22.i39.8831
Ref. | Country | Type | Age: years - Median | Sex: Male% | N LGD - prior to panel review | Follow up - median - months | Follow up - Patient years | N LGD (after panel review) consensus diagnosis | N HGD (after panel review) consensus diagnosis |
Picardo et al[27] 2015 | Ireland | R | 59 | 67% | NA | 50 | 354.17 | 85 | 60 |
Duits et al[28] 2014 | Netherlands | R | 63 | 76% | 293 | 39 | 256.75 | 79 | NA |
von Rahden et al[29] 2008 | Germany | R | 59 | 72% | NA | 24 | 114.00 | 57 | NA |
Lim et al[30] 2007 | United Kingdom | R | 67 | 80% | 34 | 96 | 112.00 | 14 | 1 |
Vieth et al[31] 2006 | Germany | R | 61 | 68% | NA | 54 | 85.50 | 19 | 10 |
Basu et al[32] 2004 | United Kingdom | R | 74 | 74% | 16 | 60 | 50.00 | 10 | 3 |
Montgomery et al[33] 2001 | United States | R | 65 | 72% | 26 | 24 | 30.00 | 15 | 15 |
Skacel et al[34] 2000 | United States | R | 67 | 84% | 25 | 26 | 36.83 | 17 | NA |
Younes et al[35] 2011 | United States | P | NA | NA | NA | 35 | 81.67 | 28 | NA |
Wani et al[10] 2011 | United States | P | 61 | 85% | 210 | 74 | 252.83 | 41 | NA |
Curvers et al[36] 2010 | Netherlands | P | 59 | 67% | 147 | 51 | 93.50 | 22 | NA |
Srivastava et al[37] 2007 | United States | P | 64 | 91% | NA | 25 | 64.58 | 31 | 46 |
Study | Patient registry | Diagnosis method of LGD | Biopsy details |
Picardo et al[27] 2015 | Specialist center based registry | Expert pathologist panel: 2 pathologists required to make diagnosis | Four-quadrant biopsies every 1 cm of Barrett's esophagus |
Duits et al[28] 2014 | Specialist center based registry | Expert pathologists panel: At-least 2 pathologists required to make diagnosis | H&E stained slides of paraffin embedded biopsy specimens |
von Rahden et al[29] 2008 | Specialist center and Community population based registry | Expert pathologists panel: 3 pathologists required to make diagnosis | Multiple biopsies at different levels of Barrett’s esophagus |
Lim et al[30] 2007 | Specialist center based registry | Expert pathologists panel: 5 pathologists required to make diagnosis | Four to ten (sometimes more) biopsies taken from Barrett's area. Hematoxylin and eosin staining |
Vieth et al[31] 2006 | Specialist center based registry | Biopsies assessed twice by two pathologists in a blinded fashion | Four biopsies every 2 cm in relation to the Barrett’s esophagus length |
Basu et al[32] 2004 | Community based cohort | Experienced gastrointestinal pathologist assessed histological sections, with confirmation by a colleague if high-grade dysplasia or worse was suspected. All cases of low-grade dysplasia were reviewed at a regular gastrointestinal histopathology meeting | 2-cm interval quadrantic biopsies in the entire length of Barrett’s esophagus |
Montgomery et al[33] 2001 | Specialist center based registry | Expert pathologists panel: 12 pathologists required to make diagnosis - reviewed blindly twice by each pathologist | Multiple biopsies at different levels of Barrett’s esophagus. Submitted biopsy specimen had to show the worst lesion that the patient was known to have at the time of the initial known endoscopy |
Skacel et al[34] 2000 | Specialist center based registry | Expert pathologists panel: LGD cases were randomized and blindly reviewed by three gastrointestinal pathologists | Four-quadrant biopsies taken using jumbo forceps at intervals of < 2 cm throughout the length of the Barrett’s segment, with additional biopsies of any endoscopic lesions. All biopsy specimens had been fixed in formalin or Hollande’s solution |
Younes et al[45] 2011 | Specialist center based registry | Expert pathologist panel: 2 pathologists required to make diagnosis | Biopsies from two or more levels in barrett's esophagus. Hematoxylin-eosin–stained sections of formalin-fixed and paraffin-embedded tissue |
Wani et al[10] 2011 | Specialist center based registry | Consensus diagnosis among two or more pathologists: defined as agreement between the local GI pathologist and expert central pathologists | At least 4 quadrant biopsies every 2 cm with either a standard or jumbo biopsy forceps. Hematoxylin Eosin stained slides of paraffin-embedded biopsy specimens |
Curvers et al[36] 2010 | Community based cohort | Expert pathologist panel: 2 pathologists required to make diagnosis | All visible abnormalities were sampled, followed by random sampling of the Barrett segment in four quadrants every 2 cm. Hematoxylin and eosin stained slides of paraffin-embedded biopsy specimens |
Srivastava et al[37] 2007 | Specialist center based registry | Expert pathologists panel: 3 pathologists required to make diagnosis | Four-quadrant endoscopic esophageal mucosal biopsies were obtained at every 1–2 cm. All four-quadrant Hollande’s or formalin fixed biopsies were embedded into one paraffin block and serial 4 µm thick tissue sections were cut and stained with hematoxylin and eosin |
- Citation: Moole H, Patel J, Ahmed Z, Duvvuri A, Vennelaganti S, Moole V, Dharmapuri S, Boddireddy R, Yedama P, Bondalapati N, Uppu A, Vennelaganti P, Puli S. Progression from low-grade dysplasia to malignancy in patients with Barrett's esophagus diagnosed by two or more pathologists. World J Gastroenterol 2016; 22(39): 8831-8843
- URL: https://www.wjgnet.com/1007-9327/full/v22/i39/8831.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i39.8831