Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury

doi:10.3748/wjg.v22.i38.8497

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2016; 22(38): 8497-8508
Published online Oct 14, 2016. doi: 10.3748/wjg.v22.i38.8497

Table 1 Effect of dietary ethanol or/and guanidinoacetate ingestion on pathology

	Control	Control + GAA	Ethanol	Ethanol + GAA
Body weight (gm)	366.71 ± 20.26^a	345.93 ± 12.30^a	301.00 ± 12.49^b	323.90 ± 12.89^a
Liver weight (gm)	9.82 ± 0.44^a	9.47 ± 0.44^a	11.70 ± 0.36^b	15.05 ± 0.71^c
Liver-to body ratio (%)	2.67 ± 0.07^a	2.74 ± 0.10^a	3.88 ± 0.25^b	4.64 ± 0.06^c
Serum ALT (U/L)	54.43 ± 1.65^a	56.57 ± 3.96^a	120.00 ± 15.59^b	222.00 ± 50.52^b
Serum AST (U/L)	63.00 ± 3.95^a	68.40 ± 10.79^a	135.23 ± 13.86^b	252.60 ± 54.19^b
Serum GAA (μmol/L)	1.92 ± 0.31^a	60.60 ± 6.73^b	2.97 ± 1.05^a	23.63 ± 1.32^c
Serum ethanol levels (mmol/L)	0 ± 0.00^a	0 ± 0.00^a	51.10 ± 4.346^b	44.94 ± 6.28^b
Hepatic GAMT activity	247.58 ± 22.31^a	412.13 ± 24.92^c	207.19 ± 22.32^b	445.198 ± 23.19^c
(pmol Creatine synthesized/min/mg protein)	247.58 ± 22.31^a	412.13 ± 24.92^c	207.19 ± 22.32^b	445.198 ± 23.19^c
Kidney AGAT activity	10.03 ± 1.17^a	2.30 ± 0.177^b	10.39 ± 1.07^a	2.882 ± 0.44^b
(nmol GAA synthesized/min/mg protein)	10.03 ± 1.17^a	2.30 ± 0.177^b	10.39 ± 1.07^a	2.882 ± 0.44^b

Data represent mean ± SEM. of n = 5 animals/group. Values not sharing a common subscript letter are statistically different, P < 0.05. AGAT: L-arginine:glycine amidinotransferase; GAA: Guanidinoacetate; AST: Aspartate transaminase; ALT: Alanine transaminase.

Citation: Osna NA, Feng D, Ganesan M, Maillacheruvu PF, Orlicky DJ, French SW, Tuma DJ, Kharbanda KK. Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury. World J Gastroenterol 2016; 22(38): 8497-8508
URL: https://www.wjgnet.com/1007-9327/full/v22/i38/8497.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i38.8497