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©The Author(s) 2016.
World J Gastroenterol. Oct 7, 2016; 22(37): 8406-8413
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8406
Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8406
Table 1 Demographic, clinical and virological characteristics of study patients n (%)
Characteristics | Total | IL28B CC | IL28B non-CC | P value |
n = 108 | n = 19 | n = 89 | ||
Age (yr), median | 53.5 (22.0-68.3) | 48.2 (22.1-66.4) | 53.8 (22.1-68.3) | 0.137 |
Female | 64 (59.3) | 8 (42.1) | 56 (62.9) | 0.094 |
Residence urban | 78 (72.2) | 17 (87.5) | 61 (68.5) | 0.090 |
Baseline ALT (mg/dL), median | 76.5 (16-890) | 103 (16-890) | 74 (17-256) | 0.031 |
Baseline HCV-RNA (log10IU/mL), median | 6.1 (4.15-7.3) | 6.2 (4.15-7.2) | 6.1 (4.15-7.3) | 0.333 |
Mild/moderate fibrosis | 38 (58.5) | 9 (69.23) | 29 (55.8) | 0.470 |
Absence of core mutations - DW | 13 (12.0) | 6 (31.6) | 7 (7.9) | 0.011 |
RVR (%) | 14 (13.0) | 7 (36.8) | 7 (7.9) | 0.003 |
EVR (%) | 43 (39.8) | 16 (84.2) | 27 (30.3) | < 0.001 |
SVR (%) | 42 (38.9) | 17 (89.5) | 25 (28.1) | < 0.001 |
Table 2 Patients characteristics related to core mutation type, univariate analysis
Characteristics | Patients withDW-type infectionn = 13 | Patients with R70Q/H and/or L91Msubstitutions n =95 | Patients withL91M substitutionn = 40 | Patients with R70Q/H substitution n = 8 | P value1 |
Age (yr) | 51.5 | 53.6 | 53.3 | 50 | a = 0.607 |
median | (29.1-66.54) | (22.1-68.3) | (24.4-67.3) | (33.8-58.8) | b = 0.694 |
c = 0.860 | |||||
Gender | 7 (53.8) | 57 (60) | 22 (55) | 5 (62.5) | a = 0.767 |
Female (%) | b = 1.000 | ||||
c = 1.000 | |||||
Residence | 11 (84.6) | 67 (70.5) | 33 (82.5) | 5 (62.5) | a = 0.509 |
Urban (%) | b = 1.000 | ||||
c = 0.325 | |||||
Baseline ALT (mg/dL) | 94 | 76 | 78 | 67 | a = 0.592 |
median | (3-235) | (16-890) | (17-890) | (54-197) | b = 0.849 |
c = 1.000 | |||||
Baseline HCV-RNA (log10IU/mL), median | 6.25 | 6.05 | 6.05 | 6.3 | a = 0.966 |
(4.15-6.9) | (4.15-7.3) | (4.1-7.3) | (5.2-7.1) | b = 1.000 | |
c = 0.414 | |||||
Mild/moderate fibrosis (F1 + F2, %) | 4 (57.1) | 34 (58.6) | 14 (58.3) | 4 (57.14) | a = 0.881 |
b = 0.925 | |||||
c = 0.283 | |||||
IL28B CC (%) | 6 (46.2) | 13 (13.7) | 8 (20.0) | 1 (12.5) | a = 0.011 |
b = 0.080 | |||||
c = 0.174 | |||||
RVR (%) | 6 (46.2) | 8 (8.4) | 4 (10.0) | 0 (0.0) | a = 0.002 |
b = 0.009 | |||||
c = 0.005 | |||||
EVR (%) | 10 (76.9) | 33 (34.7) | 15 (37.5) | 3 (37.5) | a = 0.005 |
b = 0.024 | |||||
c = 0.164 | |||||
SVR (%) | 10 (76.9) | 32 (33.7) | 15 (37.5) | 2 (25.0) | a = 0.005 |
b = 0.024 | |||||
c = 0.032 |
Table 3 Predictive factors for sustained virological response, univariate analysis n (%)
Variable | SVR n = 42 | No SVR n = 66 | P value |
Age (yr), median | 48.1 (22.1-68.3) | 54.7 (22.1-67.3) | < 0.001 |
Female gender | 22 (52.4) | 42 (63.6) | 0.246 |
Urban residence (%) | 37 (88.1) | 41 (62.1) | 0.004 |
Baseline ALT (mg/dL), median | 79 (16-890) | 75 (17-231) | 0.688 |
Baseline HCV-RNA, median | 6.2 (4.15-7.3) | 6.2 (4.8; 7.3) | 0.167 |
Mild/moderate fibrosis | 18 (75.0) | 20 (48.8) | 0.107 |
IL28B type CC (%) | 17 (40.5) | 2 (3.0) | < 0.001 |
Absence of core mutations - DW | 10 (23.8) | 3 (4.5) | 0.005 |
Presence of any core mutation, (%) | 32 (76.2) | 63 (95.5) | 0.005 |
Viral mutation in core 91 only (%) | 15 (60.0) | 25 (84.3) | 0.024 |
Viral mutation in core 70 only (%) | 2 (16.7) | 6 (66.7) | 0.032 |
RVR (%) | 13 (31.0) | 1 (1.5) | < 0.001 |
EVR (%) | 37 (88.1) | 6 (9.1) | < 0.001 |
Table 4 Multivariate analysis on independent predictive factors for sustained virological response
Variable | Adjusted OR | 95%CI | P value |
Age (< 50 yr) | 0.976 | 0.967-0.986 | < 0.001 |
Absence of core mutations | 4.710 | 1.10-21.30 | 0.04 |
IL28B polymorphism | 19.200 | 4.05-91.40 | < 0.001 |
- Citation: Sultana C, Oprişan G, Teleman MD, Dinu S, HepGen 88/2012 Project Team, Oprea C, Voiculescu M, Ruta S. Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C. World J Gastroenterol 2016; 22(37): 8406-8413
- URL: https://www.wjgnet.com/1007-9327/full/v22/i37/8406.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i37.8406