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©The Author(s) 2016.
World J Gastroenterol. Sep 28, 2016; 22(36): 8194-8202
Published online Sep 28, 2016. doi: 10.3748/wjg.v22.i36.8194
Published online Sep 28, 2016. doi: 10.3748/wjg.v22.i36.8194
Table 1 Baseline patients’ characteristics and comparison between the training and validation sets n (%)
Training set (n = 480) | Validation set (n = 437) | P value | |
Age (yr) | 67 (61-73) | 68 (61-73) | 0.684 |
Gender, male | 374 (77.9) | 331 (75.7) | 0.436 |
ECOG PS | 0.362 | ||
0 | 452 (94.2) | 405 (92.7) | |
1-2 | 28 (5.8) | 32 (7.3) | |
Child-Pugh | 0.118 | ||
A | 453 (94.4) | 401 (91.8) | |
B | 27 (5.6) | 36 (8.2) | |
MELD score | 8 (7-10) | 8 (7-10) | 0.791 |
Etiology | 0.516 | ||
Cryptogenic | 104 (21.7) | 88 (20.1) | |
HBV only | 94 (19.6) | 71 (16.2) | |
HCV only | 222 (46.25) | 217 (49.7) | |
Alcohol | 48 (10.0) | 45 (10.3) | |
HBV + HCV | 12 (2.5) | 16 (3.7) | |
HCV infection | 247 (51.5) | 246 (56.3) | 0.142 |
Portal hypertension | 165 (34.4) | 155 (35.5) | 0.728 |
Platelet count (103/μL) | 157 (25-505) | 154 (26-914) | 0.779 |
AFP, ng/mL (n = 663) | 14.3 (4.7-121.5) | 11.4 (4.3-71) | 0.160 |
ICG-R15 (n = 400) | 15 (6.1-25) | 16 (7.7-22.3) | 0.424 |
Total bilirubin (≥ 1.2 mg/dL) | 148 (30.8) | 126 (28.8) | 0.509 |
Number of lesions (> 3) | 10 (2.1) | 10 (2.3) | 0.832 |
Largest diameter (> 5 cm) | 143 (29.8) | 124 (28.4) | 0.637 |
Portal invasion | 22 (4.6) | 14 (3.2) | 0.283 |
Extent of hepatectomy (major) | 85 (17.7) | 78 (17.8) | 0.956 |
Follow-up status (dead) | 240 (50.0) | 202 (46.2) | 0.253 |
Follow-up time (mo) | 35.9 (16.3-61.0) | 32.5 (16.7-55.8) | 0.254 |
Overall survival | 59.3 (50.2-66.6) | 56.4 (47.0-75.8) | 0.833 |
Table 2 Multivariable Cox proportional hazards regression model (training set) and relative point system
Variable | HR | 95%CI | P value | β | Points |
MELD score ≤ 9 | 0 | ||||
MELD score > 9 | 1.444 | (1.080-1.931) | 0.013 | 0.3674 | 1 |
HCV infection absent | 0 | ||||
HCV infection present | 1.468 | (1.112-1.937) | 0.007 | 0.3839 | 1 |
Number of lesions ≤ 3 | 0 | ||||
Number of lesions > 3 | 3.253 | (1.434-7.380) | 0.005 | 1.1795 | 3 |
Largest diameter ≤ 5 cm | 0 | ||||
Largest diameter > 5 cm | 1.459 | (1.085-1.963) | 0.012 | 0.3779 | 1 |
Portal invasion absent | 0 | ||||
Portal invasion present | 3.500 | (2.016-6.073) | < 0.001 | 1.2526 | 3 |
Table 3 Median overall survival and 1- 3- and 5-year survival probabilities for ideal and non-ideal candidates for liver resection according to European Association for the Study of the Liver/American Association for the Study of Liver Diseases and the current study
No. Of patients (%) | Median OS (95%CI) | 5-yr OS | 10-yr OS | ||
EASL/AASLD | Ideal | 323 (37.8) | 83 (73-108) | 64.4 | 37.0 |
Non-ideal | 531 (62.2) | 46 (41-52) | 42.0 | 21.2 | |
Current study | Ideal | 593 (69.4) | 77 (64-44) | 57.2 | 31.2 |
Non-ideal | 261 (30.6) | 38 (30-44) | 35.8 | 20.0 |
- Citation: Sposito C, Di Sandro S, Brunero F, Buscemi V, Battiston C, Lauterio A, Bongini M, De Carlis L, Mazzaferro V. Development of a prognostic scoring system for resectable hepatocellular carcinoma. World J Gastroenterol 2016; 22(36): 8194-8202
- URL: https://www.wjgnet.com/1007-9327/full/v22/i36/8194.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i36.8194