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©The Author(s) 2016.
World J Gastroenterol. Sep 28, 2016; 22(36): 8187-8193
Published online Sep 28, 2016. doi: 10.3748/wjg.v22.i36.8187
Published online Sep 28, 2016. doi: 10.3748/wjg.v22.i36.8187
Table 1 Patients characteristics n (%)
Variable | n = 1163 |
Age, median (IQR) | 52 (40-62) |
Males | 644 (55) |
Etiology | |
HCV | 528 (45) |
HCV alone | 407 (35) |
Metabolic | 557 (48) |
Metabolic alone | 417 (36) |
HBV | 85 (7) |
HBV alone | 67 (6) |
Period | |
1998-2000 | 295 (25) |
2001-2003 | 251 (22) |
2004-2006 | 336 (29) |
2012-2014 | 281 (24) |
Table 2 Hepatitis C virus Etiology by period
Period | Patients, n | HCV | HCV alone | ||||
n (%) | OR (95%CI) | P value | n (%) | OR (95%CI) | P value | ||
1998-2000 (Ref.) | 295 | 157 (53) | 1 | - | 121 (41) | 1 | - |
2001-2003 | 251 | 127 (51) | 0.89 (0.63-1.24) | 0.487 | 87 (35) | 0.75 (0.53-1.06) | 0.107 |
2004-2006 | 336 | 140 (42) | 0.61 (0.45-0.84) | 0.002 | 112 (33) | 0.70 (0.50-0.97) | 0.031 |
2012-2014 | 281 | 104 (37) | 0.51 (0.36-0.71) | < 0.001 | 87 (31) | 0.64 (0.46-0.91) | 0.012 |
Table 3 Metabolic etiology by period
Period | Patients, n | Metabolic | Metabolic alone | ||||
n (%) | OR (95%CI) | P value | n (%) | OR (95%CI) | P value | ||
1998-2000 (Ref.) | 295 | 136 (46) | 1 | - | 92 (31) | 1 | - |
2001-2003 | 251 | 121 (48) | 1.08 (0.77-1.51) | 0.663 | 78 (31) | 0.98 (0.68-1.41) | 0.907 |
2004-2006 | 336 | 167 (50) | 1.14 (0.83-1.56) | 0.418 | 131 (39) | 1.37 (0.99-1.91) | 0.061 |
2012-2014 | 281 | 133 (47) | 1.01 (0.73-1.41) | 0.947 | 116 (41) | 1.53 (1.09-2.16) | 0.015 |
Table 4 Subgroup analysis hepatitis C virus etiology
Subgroup | Period | Patients, n | HCV (interaction P = 0.407) | HCV alone (interaction P = 0.252) | ||
n (%) | OR (95%CI) | n (%) | OR (95%CI) | |||
Age < 50 yr | 1998-2000 (Ref) | 132 | 68 (52) | 1 | 61 (46) | 1 |
2001-2003 | 114 | 53 (46) | 0.80 (0.48-1.32) | 35 (31) | 0.51 (0.30-0.86) | |
2004-2006 | 155 | 70 (45) | 0.74 (0.46-1.18) | 55 (35) | 0.62 (0.38-1.00) | |
2012-2014 | 111 | 45 (41) | 0.55 (0.32-0.93) | 37 (33) | 0.52 (0.30-0.89) | |
Age ≥ 50 yr | 1998-2000 (Ref) | 163 | 89 (55) | 1 | 60 (37) | 1 |
2001-2003 | 137 | 74 (54) | 0.96 (0.61-1.52) | 52 (38) | 1.03 (0.64-1.65) | |
2004-2006 | 181 | 70 (39) | 0.51 (0.33-0.79) | 57 (31) | 0.77 (0.49-1.20) | |
2012-2014 | 170 | 59 (35) | 0.46 (0.30-0.72) | 50 (29) | 0.75 (0.47-1.19) |
Table 5 Subgroup analysis metabolic etiology
Metabolic (interaction P = 0.300) | Metabolic alone (interaction P = 0.058) | |||||
Subgroup | Period | Patients, n | n (%) | OR (95%CI) | n (%) | OR (95%CI) |
Age < 50 yr | 1998-2000 (Ref.) | 132 | 56 (42) | 1 | 44 (33) | 1 |
2001-2003 | 114 | 54 (47) | 1.21 (0.73-2.00) | 41 (36) | 1.10 (0.65-1.87) | |
2004-2006 | 155 | 64 (41) | 0.93 (0.58-1.49) | 52 (34) | 0.97 (0.59-1.59) | |
2012-2014 | 111 | 52 (47) | 1.08 (0.64-1.82) | 44 (40) | 1.16 (0.67-1.99) | |
Age ≥ 50 yr | 1998-2000 (Ref.) | 163 | 80 (49) | 1 | 48 (29) | 1 |
2001-2003 | 137 | 67 (49) | 0.98 (0.62-1.55) | 37 (27) | 0.87 (0.52-1.44) | |
2004-2006 | 181 | 103 (57) | 1.36 (0.89-2.08) | 79 (44) | 1.81 (1.15-2.83) | |
2012-2014 | 170 | 81 (48) | 0.97 (0.63-1.50) | 72 (42) | 1.86 (1.18-2.94) |
- Citation: Saracco GM, Evangelista A, Fagoonee S, Ciccone G, Bugianesi E, Caviglia GP, Abate ML, Rizzetto M, Pellicano R, Smedile A. Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014. World J Gastroenterol 2016; 22(36): 8187-8193
- URL: https://www.wjgnet.com/1007-9327/full/v22/i36/8187.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i36.8187