Current hepatitis B virus infection situation in Indonesia and its genetic diversity

Table 1 Prevalence of HBsAg, anti-HBc, and anti-HBs in Indonesia

Year	Population group	HBsAg (%)	Anti-HBc (%)	Anti-HBs (%)
2007	In all provinces[11]
	General population:
	Male	9.68	36.39	34.37
	Female	9.28	30.14	28.81
	Age groups:
	1-4 yr	7.32	10.14	50.78
	5-9 yr	6.92	11.56	34.50
	10-14 yr	10.14	14.79	23.30
	In East Java province[16]
	6-12 yr	3.10	23.80	23.60
2012	In Central Kalimantan, West Timor, South East Sulawesi, provinces[41]
	1-5 yr	2.1-4.2	3.5-4.8	61.4-65.8
	In Central Kalimantan, West Timor, West Papua provinces[41]
	6-12 yr	0-5.9	5.2-50.4	20.9-40.4

Table 2 Human leukocyte antigen region in relation to susceptibility to hepatitis B virus infection

SNP region	rs	Ethnics	Ref.
HLA-DPA1	rs3077	Chinese, Japanese, Thai	[97-101]
		Korean, Indonesian
HLA-DPB1	rs9277378	Thai	[102]
	rs9277535	Chinese, Japanese, Indonesian, Taiwanese	[97-99,101,103-106]
	rs9277542	Chinese, Japanese, Korean, Thai	[100]
	rs7770370	Korean	[107]
HLA-DQ	rs9275319	Chinese	[108]
HLA-DQA2	rs9276370	Taiwanese	[104]
HLA-DQB1	rs2856718	Chinese, Japanese	[98,99]
HLA-DQB2	rs7453920	Chinese, Japanese, Taiwanese	[98,99,103,104]
HLA-DQ/DR	rs9272105	Chinese	[108]
HLA-DR	rs3135363	Indonesian	[106]
HLA-DRB1		Chinese	[109]

HLA: Human leukocyte antigen.