Case Report
Copyright ©The Author(s) 2016.
World J Gastroenterol. Jul 28, 2016; 22(28): 6559-6564
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6559
Table 1 World Health Organization criteria for SM (adapted from Valent et al 2001)[4]
Major Criteria
Multifocal dense infiltrates of mast cells (> 15 mast cells in aggregates) at bone marrow biopsy and/or in sections of other extracutaneous organ(s)
Minor Criteria
> 25% of mast cells in bone marrow are atypical cells or spindle- shaped mast cells in infiltrates detected on sections of extracutaneous organ(s)
c-kit point mutation at codon 816 in the bone marrow or in another extracutaneous organ(s)
Mast cells in the bone marrow or in the another extracutaneous organ(s) expressing CD2 and/or CD25 with CD117
Serum tryptase levels > 200 ng/mL