Copyright ©The Author(s) 2016.
World J Gastroenterol. Jul 28, 2016; 22(28): 6434-6443
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6434
Table 1 Expression and functions of guanylate-binding protein-1
GBP-1 expression
Inflammatory bowel diseasesExpressed in UC and CD[15,20,21]
Expression in epithelial cells, endothelial cells and immune cells[15,21]
Colorectal carcinomaExpression in the stroma and partially in tumor cells[15,19]
Associated with Th1-dominated angiostatic micromilieu and improved survival[19,31]
Functions of GBP-1
Endothelial cellsAnti-angiogenic, inhibits proliferation, migration, invasion and spreading; protection against apoptosis[16,44,46,47,50]
Intestinal epithelial cellsInhibits proliferation; protection against apoptosis[20,43]
Colon tumor cellsInhibits proliferation, migration, invasion and tumor growth in vivo; no induction of apoptosis (but partially required)[9]
T-cellsInhibition of spreading and early T-cell receptor signaling[54]