Primary biliary cirrhosis degree assessment by acoustic radiation force impulse imaging and hepatic fibrosis indicators

Table 1 Child-Pugh scoring criteria

Indicator	Score
	1 point	2 point	3 point
Hepatic encephalopathy (grade)	None	Slight	Occasional drowsiness
Ascites	None	Small amount of diuretics can be controlled	Numerous
Total bilirubin (μmol/L)	< 34	34-51	> 51
Albumin (g/L)	> 35	28-35	< 28
Prolonged prothrombin time(s)	< 4	4-6	> 6

Table 2 Test results of two groups of indicators (mean ± SD)

Item	Control group (n = 60)	Observation group
		A class (n = 39)	B class (n = 43)	C class (n = 38)
LS value (m/s)	1.03 ± 0.03	1.90 ± 0.07a	2.31 ± 0.02a	2.92 ± 0.17a
HA (ng/mL)	54.96 ± 21.13	431.01 ± 118.04a	619.03 ± 164.28a	857.13 ± 192.05a
LN (ng/mL)	79.11 ± 15.37	116.14 ± 18.77a	153.42 ± 36.25a	211.09 ± 30.18a
PCIII (ng/mL)	89.91 ± 18.76	142.51 ± 30.07a	227.93 ± 69.11a	367.39 ± 99.21a
IV-C (ng/mL)	51.32 ± 9.27	104.58 ± 42.17a	168.99 ± 32.14a	193.36 ± 30.22a

^aP < 0.01 vs the control group.

Table 3 Receiver operating characteristic curves results of different CP score classifications of liver cirrhosis with different indicators of diagnosis

Item	A Class			B Class			C Class
	AUC	Sensitivity	Specificity	AUC	Sensitivity	Specificity	AUC	Sensitivity	Specificity
LS value	0.852	57.9%	93.3%	0.911	97.4%	75.0%	0.936	92.1%	83.3%
HA	0.694	97.4%	55.0%	0.852	97.4%	65.0%	0.888	63.2%	96.7%
LN	0.707	97.4%	43.3%	0.746	46.2%	96.7%	0.828	97.4%	58.3%
PCIII	0.741	57.9%	86.7%	0.823	53.8%	96.7%	0.871	86.8%	75.0%
IV-C	0.688	78.9%	56.7%	0.785	97.4%	51.7%	0.889	94.7%	73.3%

Table 4 Receiver operating characteristic curve analysis for LS values combined with the four indicators of serum liver fibrosis

	LS value			Combination
	AUC	Sensitivity	Specificity	AUC	Sensitivity	Specificity
A Class	0.852	57.9%	93.3%	0.881	68.4%	91.7%
B Class	0.911	97.4%	75.0%	0.973	97.4%	85.0%
C Class	0.936	92.1%	83.3%	0.967	97.4%	90.0%