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©The Author(s) 2016.
World J Gastroenterol. Jun 14, 2016; 22(22): 5260-5266
Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5260
Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5260
Table 1 General characteristics of study patients
Variable | MG (n = 20) | PG (n = 20) | CG (n = 20) | P value |
Gender (M/F) | 8/12 | 11/9 | 7/13 | 0.725 |
Age (yr) | 43.45 ± 11.50 | 37.75 ± 10.78 | 39.95 ± 6.84 | 0.914 |
Height (cm) | 163.81 ± 12.36 | 162.36 ± 10.06 | 160.72 ± 10.63 | 0.834 |
Weight (kg) | 49.77 ± 6.79 | 48.93 ± 5.89 | 48.22 ± 5.57 | 0.973 |
BMI (kg/m2) | 18.73 ± 5.62 | 18.65 ± 4.73 | 18.84 ± 6.38 | 1.005 |
Body loss when diagnosed | 3.42 ± 0.54 | 3.72 ± 0.64 | 3.69 ± 0.71 | 0.872 |
Table 2 Change of body weight and its composition in mirtazapine group
Variable | Baseline | 2 wk | 4 wk | 6 wk | 8 wk |
Body weight (kg) | 49.77 ± 6.79 | 51.35 ± 6.80 | 52.36 ± 6.60a | 53.07 ± 6.46a | 53.35 ± 6.52a |
BMI (kg/m2) | 18.73 ± 5.62 | 18.97 ± 5.43 | 19.70 ± 4.52a | 19.87 ± 4.62a | 20.07 ± 5.23a |
Body fat (kg) | 8.36 ± 2.53 | 9.28 ± 2.33 | 11.05 ± 1.92a | 11.09 ± 1.87a | 11.13 ± 2.86a |
Body fat ratio (%) | 0.17 ± 0.02 | 0.18 ± 0.04 | 0.20 ± 0.07a | 0.20 ± 0.09a | 0.21 ± 0.08a |
Visceral fat area (cm2) | 35.27 ± 8.12 | 36.12 ± 8.05 | 41.68 ± 9.23a | 42.02 ± 9.14a | 42.83 ± 10.64a |
Muscle volume (kg) | 38.25 ± 7.53 | 38.26 ± 7.49 | 38.46 ± 6.84 | 38.52 ± 6.64 | 38.62 ± 6.77 |
Table 3 Changes of expression level of serum hormones
Group | Ghrelin (ng/mL) | Leptin (ng/mL) | NPY (pg/mL) | 5-HT (ng/mL) | CCK (pg/mL) | MTL (pg/mL) | GAS (pg/mL) | |
MG | Baseline | 4.62 ± 1.53 | 9.87 ± 4.65 | 107.52 ± 26.21 | 237.83 ± 56.94 | 392.36 ± 27.21 | 32.53 ± 6.28 | 56.37 ± 21.15 |
4 wk | 6.02 ± 3.43ace | 7.25 ± 3.47ace | 114.56 ± 25.10a | 208.47 ± 52.48a | 221.69 ± 23.77a | 49.46 ± 6.10ace | 48.37 ± 11.93ace | |
8 wk | 8.97 ± 3.64ace | 4.03 ± 2.77ace | 149.27 ± 39.53ace | 176.92 ± 53.38ace | 183.85 ± 27.65ace | 66.28 ± 3.97ace | 41.61 ± 10.52ace | |
PG | Baseline | 4.68 ± 2.12 | 9.07 ± 4.65 | 105.12 ± 29.52 | 232.83 ± 50.94 | 390.82 ± 27.54 | 31.98 ± 9.34 | 54.98 ± 15.24 |
4 wk | 5.12 ± 2.23 | 8.75 ± 3.05 | 112.31 ± 15.10a | 215.32 ± 24.91a | 291.57 ± 31.76a | 40.37 ± 8.23a | 52.37 ± 12.97 | |
8 wk | 6.01 ± 3.27a | 8.25 ± 2.13 | 114.27 ± 28.53a | 210.17 ± 49.17a | 283.85 ± 47.15a | 53.28 ± 6.84a | 48.61 ± 11.17a | |
CG | Baseline | 4.89 ± 2.47 | 8.87 ± 2.65 | 104.93 ± 17.95 | 235.81 ± 61.82 | 391.75 ± 24.96 | 36.26 ± 6.22 | 54.23 ± 26.83 |
4 wk | 5.48 ± 2.15 | 8.32 ± 3.57 | 108.92 ± 29.64 | 211.26 ± 46.28 | 224.67 ± 23.45 | 43.92 ± 7.24 | 49.21 ± 12.15 | |
8 wk | 6.93 ± 2.35 | 8.02 ± 1.45 | 121.43 ± 13.92 | 208.95 ± 38.29 | 303.12 ± 26.76 | 55.53 ± 5.98 | 43.34 ± 13.72 |
- Citation: Jiang SM, Jia L, Liu J, Shi MM, Xu MZ. Beneficial effects of antidepressant mirtazapine in functional dyspepsia patients with weight loss. World J Gastroenterol 2016; 22(22): 5260-5266
- URL: https://www.wjgnet.com/1007-9327/full/v22/i22/5260.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i22.5260