Kiani A, Brun V, Lainé F, Turlin B, Morcet J, Michalak S, Le Gruyer A, Legros L, Bardou-Jacquet E, Gandon Y, Moirand R. Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease. World J Gastroenterol 2016; 22(20): 4926-4935 [PMID: 27239119 DOI: 10.3748/wjg.v22.i20.4926]
Corresponding Author of This Article
Anita Kiani, MD, Department of Abdominal Imaging, Rennes University Hospital, CHU Rennes, 2 rue H. Le Guilloux, 35033 Rennes, France. anita.kiani@chu-rennes.fr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
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World J Gastroenterol. May 28, 2016; 22(20): 4926-4935 Published online May 28, 2016. doi: 10.3748/wjg.v22.i20.4926
Table 1 Clinical and biochemical characteristics of patients with alcoholic liver disease
Characteristic
Normal values
Patients included(n = 82)
Sex (male/female)
NA
69/13
Age (yr)
NA
43.8 ± 10
Body mass index (kg/m2)
NA
22.9 ± 4.3
AST (IU/L)
0-35
62.0 (44-98)
ALT (IU/L)
0-35
67.0 (40-105)
γ-glutamyl transpeptidase (IU/L)
5-36
316.0 (141-654)
γ-globulin (g/L)
7-15
8.7 (7.4-10.4)
Alkaline phosphatase (IU/L)
30-120
90.5 (66-121)
Prothrombin (%)
70-130
101.2 ± 12.4
Platelets (× 109/L)
180-390
191.5 ± 71.7
Iron (μmol/L)
18-22
16.2 ± 8.1
Ferritin (μg/L)
Male: 30-300
478.0 (310.5-787.5)
Female: 20-150
404.0 (216.0-783.0)
Albumin (g/L)
40-60
39.0 ± 4.9
Table 2 Number of patients and mean values of acoustic radiation force impulsepredicting for assessing liver stiffness according to the different fibrosis stages
Fibrosis stage
Number of patients
ARFI (m/s)
F0
13
1.25 ± 0.31
F1
35
1.40 ± 0.36
F2
17
1.86 ± 0.42
F3
4
1.83 ± 0.47
F4
13
2.25 ± 0.36
P value
< 0.0001
Table 3 Diagnostic performance of acoustic radiation force impulse for the different liver fibrosis stages
Diagnostic parameters
F ≥ 2
F ≥ 3
F = 4
ARFI cut-off (m/s)
1.63
1.84
1.94
Sensitivity (%)
82.4 (0.70-0.95)
82.4 (0.64-1.00)
92.3 (0.78-1.00)
Specificity (%)
83.3 (0.73-0.94)
78.5 (0.69-0.89)
81.6 (0.72-0.90)
Area under curve (AUROC)
0.87
0.86
0.89
PPV (%)
77.8 (0.64-0.91)
50.0 (0.31-0.69)
48.0 (0.28-0.68)
NPV (%)
87.0 (0.77-0.97)
94.4 (0.88-1.00)
98.2 (0.95-1.00)
Table 4 Univariate and multivariate ordinal regression analyses
Citation: Kiani A, Brun V, Lainé F, Turlin B, Morcet J, Michalak S, Le Gruyer A, Legros L, Bardou-Jacquet E, Gandon Y, Moirand R. Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease. World J Gastroenterol 2016; 22(20): 4926-4935