Copyright
©The Author(s) 2016.
World J Gastroenterol. May 14, 2016; 22(18): 4594-4603
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4594
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4594
Study or subgroup1 | Participants randomized | Mean age (yr) | Women | Follow-up (mo) | Amount of elemental calcium supplemented (mg/d) |
Vitamin D/Calcium Polyp Prevention Study[27] | 1675 | 59 | 15% | 36 or 60 | 1200 |
SWOG Calcium Chemoprevention Pilot Study[47] | 220 | 682 | 37% | 60 | 1800 |
ECP Calcium Fibre Polyp Prevention Study[28] | 439 | 59 | 37% | 36 | 2000 |
Calcium Polyp Prevention Study[51,52] | 930 | 61 | 28% | 48 | 1200 |
Illustrative comparative risks (95%CI) | |||
Assumed risk | Corresponding risk | ||
Placebo | Calcium | ||
Recurrence of adenomas (follow-up: 3 to 5 yr) | 462 per 1000 | 411 per 1000 | Relative effect (95%CI): RR = 0.89 (0.82-0.96) |
(379 to 444) | No. of patients with follow-up evaluation: 2984 | ||
No. of RCTs: 4 | |||
Quality of evidence (GRADE): ++++ (high) | |||
Advanced adenomas (follow-up: 3 to 5 yr) | 113 per 1000 | 104 per 1000 | Relative effect (95%CI): RR = 0.92 (0.75-1.13) |
(85 to 128) | No. of patients with follow-up evaluation: 2998 | ||
No. of RCTs: 4 | |||
Quality of evidence (GRADE): +++- (moderate) |
- Citation: Bonovas S, Fiorino G, Lytras T, Malesci A, Danese S. Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials. World J Gastroenterol 2016; 22(18): 4594-4603
- URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4594.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4594