Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer

Table 1 Expression of integrin αvβ6 and MMP-9 and patient characteristics

Characteristic	No.	αvβ6		P value	MMP-9		P value
		Negative	Positive		Negative	Positive
Age (yr)
< 60	51	33	18		31	20
> 60	75	49	26	0.942	42	33	0.593
Gender
Male	78	50	28		43	35
Female	48	32	16	0.769	30	18	0.416
Location
Upper	27	20	7		16	11
Middle	51	28	23		28	23
Lower	48	34	14	0.136	29	19	0.847
Lauren type
Intestinal	83	47	36		46	37
Diffuse	43	35	8	0.006	27	16	0.427
Differentiation
Well	19	15	4		6	13
Moderate	30	14	16		18	12
Poor	77	53	24	0.038	49	28	0.039
T stage
T1	14	10	4		3	11
T2	13	7	6		8	5
T3	18	10	8		14	4
T4	81	55	26	0.578	48	33	0.014
N stage
N0	37	26	11		18	19
N1	17	12	5		10	7
N2	26	10	16		11	15
N3	46	34	12	0.016	34	12	0.033
M stage
M0	124	81	43		73	51
M1	2	1	1	0.652	0	2	0.094
TNM stage
I	12	4	8		3	9
II	42	36	6		22	20
III	70	41	29		48	22
IV	2	1	1	0.002	0	2	0.008

MMP-9: Matrix metalloproteinase 9.

Table 2 Expression correlation of integrin αvβ6 and MMP-9

αvβ6 expression	MMP-9 expression		Total
	Negative	Positive
Negative	56	26	82
Positive	17	27	44
Total	73	53	126

MMP-9: Matrix metalloproteinase 9.

Table 3 Univariate and multivariate analyses comparing overall survival to prognostic factors in 126 gastric cancer patients

Factors	Univariate analysis		Multivariate analysis
	Relative risk (95%CI)	P value	Relative risk (95%CI)	P value
Age (yr)
< 60	1
> 60	1.800 (1.090-2.973)	0.258
Gender
Female	1
Male	1.450 (0.882-2.381)	0.143
Location
Upper	1
Middle/Lower	1.171 (0.856-1.602)	0.323
Lauren type
Intestinal	1
Diffuse	1.836 (1.061-3.177)	0.03	1.431 (0.805-2.545)	0.222
Differentiation
Well	1
Moderate/Poor	1.045 (0.764-1.429)	0.784
T stage
T1	1		1
T2-4	1.295 (1.006-1.668)	0.050	1.248 (0.813-1.916)	0.311
N stage
N0	1		1
N1-3	1.343 (1.105-1.633)	0.003	1.249 (0.818-1.909)	0.303
M stage
M0	1		1
M1	26.25 (2.887-238.81)	0.004	8.555 (0.735-99.62)	0.087
TNM stage
I	1		1
II-IV	2.314 (1.502-3.565)	< 0.001	1.654 (0.643-4.257)	0.296
αvβ6
Negative	1		1
Positive	2.862 (1.452-3.747)	< 0.001	2.632 (1.569-4.416)	0.003
MMP-9
Negative	1		1
Positive	2.193 (1.110-2.787)	0.005	1.813 (1.398-2.351)	0.007

MMP-9: Matrix metalloproteinase 9.