Operative link on gastritis assessment stage is an appropriate predictor of early gastric cancer

Table 1 Clinicopathological characteristics and endoscopic gastric atrophy classification

	EGC group	Non-EGC group	P value
Total patients, n (%)	71 (100)	156 (100)
Sex, n (%)			> 0.050
Male	51 (71.8)	98 (62.8)
Female	20 (28.2)	58 (37.2)
Age (yr)	64.0 ± 9.1	62.2 ± 7.4	> 0.050
H. pylori infection rate	70.4%	61.5%	> 0.050
EGA classification			< 0.001
C0	1	6
C1	3	18
C2	21	62
C3	7	29
O1	23	30
O2	12	11
O3	4	0
Atrophic rate	98.6%	96.2%	> 0.050
OLGA stage			< 0.001
0	1	6
I	16	65
II	17	49
III	27	27
IV	10	9
OLGIM stage			< 0.001
0	6	45
I	17	47
II	18	33
III	20	23
IV	10	8
IM rate	91.5%	71.2%	0.001
IM subtype			0.019
Complete IM	13	41
Incomplete IM	52	70

EGA: Endoscopic gastric atrophy; EGC: Early gastric cancer; H. pylori: Helicobacter pylori; IM: Intestinal metaplasia; OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link on Intestinal Metaplasia Assessment.

Table 2 Endoscopic gastric atrophy classification and OLGA/OLGIM stage in early gastric cancer and non- early gastric cancer patients

	EGC group	Non-EGC group	P value	OR (95%CI)
EGA classification1			0.005	2.26 (1.27-4.04)
None-to-mild	25	86
Moderate-to-severe	46	70
OLGA stage			< 0.001	3.76 (2.07-6.85)
0-II	34	121
III-IV	37	35
OLGIM stage			< 0.001	2.95 (1.60-5.45)
0-II	41	125
III-IV	30	31

¹None-to-mild EGA, C0-C2 types of EGA classification; Moderate-to-severe EGA, C3-O3 types of EGA classification. CI: Confidence interval; EGA: Endoscopic gastric atrophy; EGC: Early gastric cancer; OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link on Intestinal Metaplasia Assessment; OR: Odds ratio.

Table 3 Relation between early gastric cancer classification and OLGA/OLGIM stage n (%)

	EGA classification		P value
	None-to-mild	Moderate-to-severe
OLGA stage			0.001
0-II	87 (56.1)	68 (43.9)
III-IV	24 (33.3)	48 (66.7)
OLGIM stage			< 0.001
0-II	94 (56.6)	72 (43.4)
III-IV	17 (27.9)	44 (72.1)

EGA: Endoscopic gastric atrophy; OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link on Intestinal Metaplasia Assessment.

Table 4 Relation between OLGA/OLGIM stage and IM stage

	OLGIM
		Stage 0	Stage I	Stage II	Stage III	Stage IV
OLGA	Stage 0	7	0	0	0	0
	Stage I	29	41	8	3	0
	Stage II	14	15	32	5	0
	Stage III	1	7	10	33	3
	Stage IV	0	1	1	2	15

OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link on Intestinal Metaplasia Assessment.

Table 5 Logistic regression analysis of three risk factors for early gastric cancer

	OR (95%CI)	P value
Moderate-to-severe EGA	1.95 (1.06-3.58)	0.031
OLGA stages III-IV	3.14 (1.71-5.81)	< 0.001
OLGIM stages III-IV	-	0.781

CI: Confidence interval; EGA: Endoscopic gastric atrophy; EGC: Early gastric cancer; OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link on Intestinal Metaplasia Assessment; OR: Odds ratio.

Table 6 Comparison of H. pylori infection rates between different groups

	Group	H. pylori infection rate	P value
EGA classification	None-mild degree	54.1%	0.001
	Moderate-severe degree	75.0%
OLGA stage	0-II	55.8%	< 0.001
	III-IV	83.6%
OLGIM stage	0-II	57.8%	< 0.001
	III-IV	83.6%
IM subtype	Complete	68.5%	0.949
	Incomplete	68.0%

EGA: Endoscopic gastric atrophy; EGC: Early gastric cancer; IM: Intestinal metaplasia; OLGA: Operative Link for Gastritis Assessment; OLGIM: Operative Link on Intestinal Metaplasia Assessment.