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©The Author(s) 2016.
World J Gastroenterol. Apr 7, 2016; 22(13): 3663-3669
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3663
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3663
Table 1 Baseline characteristics of the subjects with and without non-alcoholic fatty liver disease
Variable | NAFLD | Non-NAFLD | t value | P value |
Age (yr) | 43.38 (0.42) | 40.14 (0.35) | 5.944 | < 0.001 |
Gender, male/female (n) | 598/93 | 685/572 | 203.663 | < 0.001 |
BMI (kg/m2) | 25.69 (0.09) | 21.83 (0.07) | 33.044 | < 0.001 |
SBP (mmHg) | 128.62 (0.6) | 117.49 (0.43) | 15.253 | < 0.001 |
DBP (mmHg) | 79.73 (0.36) | 72.71 (0.27) | 15.608 | < 0.001 |
Hb (g/L) | 151.3 (0.46) | 141.62 (0.41) | 15.679 | < 0.001 |
PLT (× 109/L) | 209.44 (2.12) | 206.1 (1.5) | 1.299 | 0.194 |
WBC (× 109/L) | 6.48 (0.06) | 5.91 (0.04) | 8.294 | < 0.001 |
SUA (μmol/L) | 367.92 (3.45) | 291.89 (2.32) | 18.742 | < 0.001 |
FPG (mmol/L) | 5.01 (0.05) | 4.59 (0.02) | 8.019 | < 0.001 |
TG (mmol/L) | 2.47 (0.07) | 1.3 (0.03) | 15.096 | < 0.001 |
TC (mmol/L) | 4.94 (0.03) | 4.6 (0.02) | 8.128 | < 0.001 |
LDL (mmol/L) | 2.35 (0.03) | 2.16 (0.03) | 4.487 | < 0.001 |
VLDL (mmol/L) | 1.41 (0.03) | 1.01 (0.02) | 10.996 | < 0.001 |
HLDL (mmol/L) | 1.16 (0.01) | 1.44 (0.01) | -20.396 | < 0.001 |
ALT (U/L) | 36.24 (0.9) | 19.75 (0.41) | 16.649 | < 0.001 |
AST (U/L) | 27.21 (0.43) | 22.1 (0.25) | 10.200 | < 0.001 |
γ-GT (U/L) | 49.97 (1.51) | 25.56 (0.99) | 13.512 | < 0.001 |
Table 2 Age and sex distribution of overall non-alcoholic fatty liver disease prevalence
Age (yr) | Total | NAFLD | Overall | Males | Females | χ2value | P value |
< 20 | 3 | 0 | 0.00% | 0.00% | 0.00% | - | - |
20-29 | 342 | 69 | 20.18% | 28.07% | 4.39% | 26.471 | < 0.001 |
30-39 | 559 | 183 | 32.74% | 44.14% | 10.94% | 63.114 | < 0.001 |
40-49 | 608 | 245 | 40.30% | 55.01% | 14.16% | 97.223 | < 0.001 |
50-59 | 259 | 134 | 51.74% | 60.00% | 28.99% | 19.499 | < 0.001 |
60-69 | 119 | 47 | 39.50% | 48.00% | 25.00% | 6.139 | 0.013 |
≥ 70 | 58 | 13 | 22.41% | 25.00% | 19.23% | 0.275 | 0.600 |
Total | 1948 | 691 | 35.47% | 46.61% | 13.98% | 203.663 | < 0.001 |
Table 3 Logistic regression analysis of risk factors associated with the prevalence of non-alcoholic fatty liver disease
Variables | B | S.E. | Wals | Sig. | OR | 95%CI of OR | |
Age | 0.025 | 0.007 | 14.767 | < 0.001 | 1.025 | 1.012 | 1.038 |
BMI | 0.450 | 0.036 | 158.411 | < 0.001 | 1.569 | 1.462 | 1.682 |
PLT | 0.004 | 0.001 | 6.898 | 0.009 | 1.004 | 1.001 | 1.006 |
SUA | 0.006 | 0.001 | 28.372 | < 0.001 | 1.006 | 1.004 | 1.008 |
FPG | 0.334 | 0.081 | 16.884 | < 0.001 | 1.397 | 1.191 | 1.638 |
TG | 0.280 | 0.089 | 9.919 | 0.002 | 1.323 | 1.112 | 1.575 |
VLDL | 0.336 | 0.118 | 8.148 | 0.004 | 1.400 | 1.111 | 1.764 |
HDL | -1.053 | 0.298 | 12.469 | < 0.001 | 0.349 | 0.194 | 0.626 |
ALT | 0.049 | 0.008 | 37.985 | < 0.001 | 1.050 | 1.034 | 1.067 |
AST | -0.064 | 0.014 | 20.903 | < 0.001 | 0.938 | 0.912 | 0.964 |
Table 4 Comparison of variables between baseline and end point in subjects who developed non-alcoholic fatty liver disease
Variables | Difference | t value | P value |
BMI (kg/m2) | -1.454 | -17.198 | 0.000 |
SBP (mmHg) | -4.875 | -6.105 | 0.000 |
DBP (mmHg) | -2.225 | -4.021 | 0.000 |
Hb (g/L) | -3.537 | -6.972 | 0.000 |
PLT (× 109/L) | -7.352 | -3.276 | 0.001 |
WBC (× 109/L) | -0.283 | -3.728 | 0.000 |
SUA (μmol/L) | -29.304 | -8.814 | 0.000 |
FPG (mmol/L) | -0.463 | -10.909 | 0.000 |
TG (mmol/L) | -0.224 | -2.630 | 0.009 |
TC (mmol/L) | -0.268 | -6.823 | 0.000 |
LDL (mmol/L) | 0.054 | 1.368 | 0.172 |
VLDL (mmol/L) | -0.295 | -11.043 | 0.000 |
HDL (mmol/L) | 0.126 | 10.200 | 0.000 |
ALT (U/L) | -3.099 | -2.672 | 0.008 |
AST (U/L) | 0.006 | 0.009 | 0.993 |
γ-GT (U/L) | -10.43 | -4.912 | 0.000 |
Table 5 Comparison of variables between baseline and end point in subjects who seceded from non-alcoholic fatty liver disease
Variables | Difference | t value | P value |
BMI (kg/m2) | 0.801 | 4.759 | 0.000 |
SBP (mmHg) | -2.285 | -1.509 | 0.134 |
DBP (mmHg) | -0.279 | -0.274 | 0.784 |
Hb (g/L) | -0.434 | -0.496 | 0.621 |
PLT (× 109/L) | 0.754 | 0.203 | 0.839 |
WBC(× 109/L) | -0.040 | -0.274 | 0.785 |
SUA (μmol/L) | 12.800 | 1.820 | 0.072 |
FPG (mmol/L) | -0.204 | -2.329 | 0.022 |
TG (mmol/L) | 0.643 | 6.159 | 0.000 |
TC (mmol/L) | 0.209 | 2.721 | 0.007 |
LDL (mmol/L) | 0.357 | 4.532 | 0.000 |
VLDL (mmol/L) | 0.073 | 1.544 | 0.125 |
HDL (mmol/L) | -0.005 | -0.194 | 0.846 |
ALT (U/L) | 8.950 | 5.917 | 0.000 |
AST (U/L) | 5.084 | 5.997 | 0.000 |
γ-GT (U/L) | 9.557 | 4.612 | 0.000 |
- Citation: Lu ZY, Shao Z, Li YL, Wulasihan M, Chen XH. Prevalence of and risk factors for non-alcoholic fatty liver disease in a Chinese population: An 8-year follow-up study. World J Gastroenterol 2016; 22(13): 3663-3669
- URL: https://www.wjgnet.com/1007-9327/full/v22/i13/3663.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i13.3663