Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis

doi:10.3748/wjg.v22.i12.3451

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 12

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7755)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-5) series, Tables (1-7) series.

Item

Count

PDF

622

WORD

321

HTML

4539

Figures (1-5)

195

Tables (1-7)

184

Sum=5861

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

739

Download

1155

Sum=1894

Mar 28, 2016 (publication date) through Aug 24, 2024

Times Cited of This Article

Times Cited (25)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Gastroenterol. Mar 28, 2016; 22(12): 3451-3459
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3451

Table 1 Comparison of age, sex and duration of remission

	Healthy group	UC remission group	IBS-D group
Cases	30	33	30
Age (yr), mean age	23-62, (42.5 ± 19.5)	22-56, (39 ± 17)	18-60, (39 ± 21)
Sex	15 females, 15 males	15 females, 18 males	16 males, 14 females
Duration (yr)	None	1.8 ± 18.2	1.6 ± 20.4

UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 2 Comparisons of changes in the gastrointestinal symptom scores of patients in each group (mean ± SD)

Symptom	Normal	IBS-D	UC in remission
Abdominal pain or discomfort	0.25 ± 0.05	1.84 ± 0.67^a	2.84 ± 0.81^b
Stool frequency	0.55 ± 0.05	1.46 ± 0.58^a	2.34 ± 0.76^b
Stool	0.75 ± 0.05	1.44 ± 0.67^a	1.89 ± 0.87^b
Mucus	0.10 ± 0.03	1.04 ± 0.84^b	1.58 ± 0.67^b
Defecation	0.55 ± 0.05	1.06 ± 0.74	1.86 ± 0.86^b
Total score	1.75 ± 0.23	6.83 ± 1.86^a	9.51 ± 1.91^b

^aP < 0.05,

^bP < 0.01 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 3 Testing of anorectal motility and rectal visceral sensation in each group

	Normal	IBS-D	UC in remission
Initial sensory threshold (mL)	50.18 ± 4.19	23.91 ± 10.15^a	20.10 ± 9.17^b
Defecation threshold (mL)	69.15 ± 10.75	35.17 ± 12.71^a	21.28 ± 10.32^b
Pain threshold (mL)	105.90 ± 20.15	70.10 ± 11.25^a	50.33 ± 12.30^b
Maximum compliance (mL/mmHg)	4.95 ± 1.81	5.02 ± 1.75	4.98 ± 1.91
Resting pressure (mmHg)	62.15 ± 15.21	65.54 ± 13.15	63.27 ± 10.15
Relaxation pressure (mmHg)	105.15 ± 60.15	140.50 ± 55.50^a	138.69 ± 52.82^a
Relaxation pressure (mmHg)	43.18 ± 22.50	45.15 ± 20.65	46.10 ± 19.97

^aP < 0.05,

^bP < 0.01 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 4 Comparison of 5-HT and 5-HIAA concentrations in each group (mean ± SD)

	5-HT (nmol/L)	5-HIAA (nmol/L)
Normal	10.55 ± 1.35	1.15 ± 0.15
IBS-D	35.31 ± 2.15^a	8.50 ± 1.50^a
UC in remission	33.85 ± 1.55^a	8.15 ± 1.35^a

^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 5 TPH1 protein expression in the colonic mucosa of patients in each group

Group	TPH1
Normal	0.032 ± 0.015
IBS-D	0.183 ± 0.034^a
UC in remission	0.185 ± 0.027^a

^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 6 5-HT3R, 4R, and 7R receptor mRNA expression levels in each group

Group	5-HT3R	5-HT4R	5-HT7R
Normal	0.086 ± 0.05	0.155 ± 0.0913	0.1097 ± 0.0405
IBS-D	0.499 ± 0.012^a	0.013 ± 0.067^a	0.0911 ± 0.0501^a
UC in remission	0.954 ± 0.022^a	0.015 ± 0.059^a	0.1711 ± 0.0845^a

^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Table 7 Comparison of serotonin transporter protein gray values

Group	Cases	Mean gray value
Normal	30	154.8 ± 10.5
IBS-D	30	169.1 ± 10.1^a
Ulcerative colitis	33	173.0 ± 8.4^a

^aP < 0.05 vs normal. IBS-D: Diarrhea-predominant irritable bowel syndrome.

Citation: Yu FY, Huang SG, Zhang HY, Ye H, Chi HG, Zou Y, Lv RX, Zheng XB. Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. World J Gastroenterol 2016; 22(12): 3451-3459
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3451.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3451