Bruha R, Jachymova M, Petrtyl J, Dvorak K, Lenicek M, Urbanek P, Svestka T, Vitek L. Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis. World J Gastroenterol 2016; 22(12): 3441-3450 [PMID: 27022226 DOI: 10.3748/wjg.v22.i12.3441]
Corresponding Author of This Article
Radan Bruha, MD, PhD, 4th Department of Internal Medicine, General University Hospital, U Nemocnice 2, 12808 Prague, Czech Republic. bruha@cesnet.cz
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 4 Laboratory and clinical parameters in different Child-Pugh groups of patients
Parameter
Child-Pugh A
Child-Pugh B
Child-Pugh C
P value
Age (yr)
55.6 ± 10.7
52.9 ± 11.2
56.3 ± 10.7
NS
Osteopontin (ng/mL)
84.8 ± 34.9
158.8 ± 98.2
205.2 ± 142.8
A vs B, P < 0.001, A vs C, P < 0.001, B vs C, NS
HVPG (mmHg)
14.1 ± 5.1
17.1 ± 4.8
19.5 ± 4.5
A vs B, P < 0.001, A vs C, P < 0.001, B vs C, NS
Survival (yr)
4.6 ± 2.3
3.3 ± 2.5
2.5 ± 2.6
A vs C, P < 0.001, A vs B, NS, B vs C, NS
Table 5 Correlation of hemodynamic evaluation of portal hypertension and osteopontin to clinical parameters in patients with liver cirrhosis
Parameter
HVPG
Osteopontin
r
P value
r
P value
Survival
0.220
0.009
0.230
0.006
Platelet counts
0.247
0.005
0.231
0.009
Size of varices
0.352
< 0.001
0.009
0.927
History of bleeding from varices
< 0.001
0.506
Presence of ascites
< 0.001
< 0.001
Citation: Bruha R, Jachymova M, Petrtyl J, Dvorak K, Lenicek M, Urbanek P, Svestka T, Vitek L. Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis. World J Gastroenterol 2016; 22(12): 3441-3450