Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

doi:10.3748/wjg.v22.i12.3372

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World Journal of Gastroenterology

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1007-9327

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Case Control Study

World J Gastroenterol. Mar 28, 2016; 22(12): 3372-3380
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3372

Table 1 Age, sex, and genotype frequencies of the cases and controls n (%)

Variable	Cases	Controls	P value¹
Variable	n = 727	n = 736	P value¹
Age (mean ± SD), yr	60.3 ± 12.8	60.7 ± 13.0	0.639
Gender			0.751
Male	410 (56.4)	409 (55.6)
Female	317 (43.6)	327 (44.4)
Colon/rectum, n	352/375
OGG1 Ser326Cys			0.021
Ser/Ser	93 (13.0)	125 (17.1)
Ser/Cys	363 (50.8)	324 (44.4)
Cys/Cys	258 (36.1)	281 (38.5)
Missing	13	6
OGG1 11657A/G			0.318
A/A	648 (91.9)	654 (90.1)
A/G	55 (7.8)	72 (9.9)
G/G	2 (0.3)	0 (0.0)
Missing	22	10
OGG1 Arg154His			0.158
Arg/Arg	720 (100.0)	720 (99.7)
Arg/His	0 (0.0)	2 (0.3)
His/His	0 (0.0)	0 (0.0)
Missing	7	14
APE1 Asp148Glu			0.567
Asp/Asp	236 (33.0)	249 (34.3)
Asp/Glu	349 (48.8)	361 (49.7)
Glu/Glu	130 (18.2)	117 (16.1)
Missing	12	9
APE1 T-656G			0.876
T/T	217 (30.1)	211 (28.9)
T/G	368 (51.0)	380 (52.0)
G/G	136 (18.9)	140 (19.2)
Missing	6	5

¹Continuous variables were tested by Student’s t-test, and categorical variables were tested by χ² or Mantel-Haenszel χ² test.

Table 2 Distribution of OGG1 and APE1 polymorphisms between cases and controls n (%)

Genotype	Cases	Controls	OR (95%CI)¹	P value
OGG1 Ser326Cys
Ser/Ser	93 (13.0)	125 (17.1)	1.00 (ref)
Ser/Cys	363 (50.8)	324 (44.4)	1.51 (1.11-2.05)	0.009
Cys/Cys	258 (36.1)	281 (38.5)	1.23 (0.90-1.69)	0.198
Ser/Cys + Cys/Cys	621 (87.0)	605 (82.9)	1.38 (1.03-1.85)	0.030
OGG1 11657A/G
A/A	648 (91.9)	654 (90.1)	1.00 (ref)
A/G	55 (7.8)	72 (9.9)	0.77 (0.53-1.12)	0.168
G/G	2 (0.3)	0 (0.0)	-
A/G + G/G	57 (8.1)	72 (9.9)	0.80 (0.56-1.15)	0.230
APE1 Asp148Glu
Asp/Asp	236 (33.0)	249 (34.3)	1.00 (ref)
Asp/Glu	349 (48.8)	361 (49.7)	1.02 (0.81-1.29)	0.864
Glu/Glu	130 (18.2)	117 (16.1)	1.17 (0.86-1.60)	0.308
Asp/Glu + Glu/Glu	479 (67.0)	478 (65.8)	1.06 (0.85-1.32)	0.615
APE1 T-656G
T/T	217 (30.1)	211 (28.9)	1.00 (ref)
T/G	368 (51.0)	380 (52.0)	0.94 (0.74-1.20)	0.630
G/G	136 (18.9)	140 (19.2)	0.95 (0.70-1.28)	0.731
T/G + G/G	504 (69.9)	520 (71.1)	0.95 (0.75-1.18)	0.621

¹ORs and 95%CIs were estimated from unconditional logistic regressions after controlling for age and sex.

Table 3 Odds ratio and 95%CI of two OGG1 single nucleotide polymorphisms for colorectal cancer stratified by sex, age at diagnosis, and tumor site and stage

	OGG1 Ser326Cys				OGG1 11657A/G
	Ser/Ser		Ser/Cys + Cys/Cys		A/A		A/G + G/G
	No.¹	OR (95%CI)²	No.¹	OR (95%CI)²	No.¹	OR (95%CI)²	No.¹	OR (95%CI)²
Gender
Male	50/67	1.00 (ref)	350/340	1.38 (0.93-2.05)	364/358	1.00 (ref)	31/47	0.65 (0.40-1.05)
Female	43/58	1.00 (ref)	271/265	1.38 (0.90-2.12)	284/296	1.00 (ref)	26/25	1.09 (0.61-1.93)
Age at diagnosis (yr)
≤ 60	44/54	1.00 (ref)	275/264	1.28 (0.83-1.97)	292/283	1.00 (ref)	23/32	0.70 (0.40-1.22)
> 60	49/71	1.00 (ref)	346/341	1.47 (0.99-2.17)	356/371	1.00 (ref)	34/40	0.89 (0.55-1.43)
Tumor site
Colon	45/125	1.00 (ref)	299/605	1.39 (0.96-2.01)	316/654	1.00 (ref)	23/72	0.67 (0.41-1.09)
Rectum	48/125	1.00 (ref)	322/605	1.39 (0.97-1.99)	332/654	1.00 (ref)	34/72	0.93 (0.61-1.43)
Stage
0, I, II	46/125	1.00 (ref)	283/605	1.28 (0.88-1.84)	307/654	1.00 (ref)	20/72	0.59 (0.35-0.98)^a
III, IV	47/125	1.00 (ref)	338/605	1.48 (1.03-2.13)^a	341/654	1.00 (ref)	37/72	0.99 (0.65-1.51)

¹Number of cases/number of controls;

²Adjustment for age and sex (except in gender stratification, where only sex was adjusted for). The

^aP < 0.05 is the comparison between CRC patients in stage 0, I, II and controls in calculating OR for A/G + G/G genotype vs A/A genotype.

Table 4 Odds ratio and 95%CI of two APE1 single nucleotide polymorphisms for colorectal cancer stratified by sex, age at diagnosis, and tumor site and stage

	APE1 Asp148Glu				APE1 T-656G
	Asp/Asp		Asp/Glu + Glu/Glu		T/T		T/G + G/G
	No.¹	OR (95%CI)²	No.¹	OR (95%CI)²	No.¹	OR (95%CI)²	No.¹	OR (95%CI)²
Gender
Male	137/122	1.00 (ref)	264/283	0.83 (0.62-1.12)	128/111	1.00 (ref)	277/296	0.81 (0.60-1.10)
Female	99/127	1.00 (ref)	215/195	1.41 (1.02-1.96)^a	89/100	1.00 (ref)	227/224	1.14 (0.81-1.60)
Age at diagnosis (yr)
≤ 60	105/110	1.00 (ref)	213/205	1.09 (0.78-1.51)	108/99	1.00 (ref)	215/219	0.90 (0.65-1.26)
> 60	131/139	1.00 (ref)	266/273	1.03 (0.77-1.38)	109/112	1.00 (ref)	289/301	0.99 (0.73-1.35)
Tumor site
Colon	114/249	1.00 (ref)	231/478	1.06 (0.81-1.40)	105/211	1.00 (ref)	244/520	0.94 (0.71-1.25)
Rectum	122/249	1.00 (ref)	248/478	1.05 (0.81-1.38)	112/211	1.00 (ref)	260/520	0.95 (0.72-1.24)
Stage
0, I, II	106/249	1.00 (ref)	226/478	1.11 (0.84-1.47)	107/211	1.00 (ref)	226/520	0.85 (0.64-1.12)
III, IV	130/249	1.00 (ref)	253/478	1.02 (0.79-1.33)	110/211	1.00 (ref)	278/520	1.03 (0.79-1.36)

¹Number of cases/number of controls;

²Adjustment for age and sex (except in gender stratification, where only sex was adjusted for). The

^aP < 0.05 is the comparison between CRC cases and controls among female in calculating OR for Asp/Glu + Glu/Glu genotype vs Asp/Asp genotype.

Table 5 Odds ratio and 95%CI of APE1 haplotypes for colorectal cancer stratified by sex, age at diagnosis, and tumor site and stage

	APE1 Asp148Glu/T-656G
	Asp/T		Asp/G		Glu/T		Glu/G
	Ca/Co (%)¹	OR (95%CI)²	Ca/Co (%)¹	OR (95%CI)²	Ca/Co (%)¹	OR (95%CI)²	Ca/Co (%)¹	OR (95%CI)²
All	41.1/41.5	1.00 (ref)	16.3/17.7	0.93 (0.75-1.15)	14.5/13.4	1.09 (0.87-1.37)	28.1/27.5	1.03 (0.86-1.24)
Gender
Male	42.5/40.0	1.00 (ref)	16.0/16.8	0.87 (0.66-1.16)	14.5/14.6	0.91 (0.67-1.22)	27.1/29.7	0.84 (0.66-1.06)
Female	39.3/44.6	1.00 (ref)	16.7/18.9	1.00 (0.73-1.36)	14.5/11.8	1.39 (0.98-1.97)	29.5/24.7	1.36 (1.03-1.78)^a
Age at diagnosis (yr)
≤ 60	42.1/42.7	1.00 (ref)	17.1/17.2	1.01 (0.74-1.38)	15.7/14.8	1.08 (0.77-1.50)	25.0/25.3	1.00 (0.76-1.32)
> 60	40.3/40.5	1.00 (ref)	15.6/18.1	0.87 (0.65-1.15)	13.5/12.3	1.10 (0.81-1.50)	30.6/29.1	1.06 (0.84-1.34)
Tumor site
Colon	40.4/41.5	1.00 (ref)	16.7/17.7	0.96 (0.74-1.25)	15.5/13.4	1.20 (0.91-1.58)	27.4/27.5	1.03 (0.82-1.28)
Rectum	41.7/41.5	1.00 (ref)	16.0/17.7	0.90 (0.69-1.16)	13.5/13.4	0.99 (0.75-1.31)	28.8/27.5	1.04 (0.84-1.29)
Stage
0, I, II	41.1/41.5	1.00 (ref)	15.8/17.7	0.90 (0.69-1.17)	14.9/13.4	1.14 (0.86-1.51)	28.2/27.5	1.02 (0.82-1.28)
III, IV	41.1/41.5	1.00 (ref)	16.7/17.7	0.95 (0.74-1.23)	14.1/13.4	1.06 (0.81-1.39)	28.1/27.5	1.04 (0.84-1.29)

¹Percentage of cases/percentage of controls;

²Adjustment for age and sex (except in gender stratification, where only sex was adjusted for). The

^aP < 0.05 is the comparison between CRC cases and controls among female in calculating OR for Glu/G haplotype vs Asp/T haplotype.

Citation: Lai CY, Hsieh LL, Tang R, Santella RM, Chang-Chieh CR, Yeh CC. Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan. World J Gastroenterol 2016; 22(12): 3372-3380
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3372.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3372