Proteoglycans in liver cancer

Table 1 Classification of proteoglycans

Localization	Eponym	Gene symbol	GAG
Intracellular	Serglycin	SRGN	Hep
Membrane
SLIPs
	Syndecan-1	SDC1	HS/CS
	Syndecan 2-4	SDC2-4	HS
GRIPs
	Glypican 1-6	GPC 1-6	HS/CS
Other
	Betaglycan	TGFBR3	HS/CS
	CD44	CD44	CS
Extracellular
SLRPs
Class I
	Decorin	DCN	DS/CS
	Biglycan	BGN	CS
	Asporin	ASPN	-
Class II
	Fibromodulin	FMOD	KS
	Lumican	LUM	KS
	Keratocan	KERA	KS
	PRELP	PRELP	-
	Osteoadherin	OMD	KS
Class III
	Epiphycan	EPYC	CS/DS
	Osteoglycin	OGN	-
Pericellular
BM zone
	Agrin	AGRN	HS
	Collagen XVIII	COL18A1	HS
	Aggrecan	ACAN	CS/KS
Hyalectans
	Versican	VCAN	CS
	Neurocan	NCAN	CS
	Brevican	BCAN	CS

SLIPs: Syndecan-like integral membrane proteoglycans; GRIPs: Glypican-related integral membrane heparan sulfate proteoglycans; SLRPs: Small leucine-rich proteoglycans; BM: Basement membrane.