Evaluation of changes of serum hepatitis B surface antigen from a different perspective

Table 1 Dynamic changes of serum hepatitis B surface antigen and serum hepatitis B surface antigen apportioned by the same hepatic parenchyma cell volume in different inflammation grades and fibrosis stages

	Case, n	Serum HBsAg(log10 COI)	Serum HBsAg apportioned bythe same HPCV (log10 COI)
G1	44	3.66 ± 0.40	5.57 ± 0.62
G2	54	3.74 ± 0.35	5.98 ± 0.65
G3	35	3.74 ± 0.26	6.59 ± 0.50
G4	27	3.71 ± 0.34	6.81 ± 0.84
S1	53	3.66 ± 0.43	5.53 ± 0.66
S2	40	3.75 ± 0.33	5.98 ± 0.53
S3	30	3.71 ± 0.28	6.29 ± 0.46
S4	37	3.75 ± 0.26	7.06 ± 0.48

Data are shown as mean ± SD. HBsAg: Hepatitis B surface antigen; HPCV: Hepatic parenchyma cell volume; G: Liver inflammation grade; S: Hepatic fibrosis stage; COI: Cut off index.

Table 2 Statistical analysis of dynamic changes of serum hepatitis B surface antigen and serum hepatitis B surface antigen apportioned by the same hepatic parenchyma cell volume in different inflammation grades and fibrosis stages

	Serum HBsAg	Serum HBsAg apportioned by HPCV		Serum HBsAg	Serum HBsAg apportioned by HPCV
G1 + G2	0.233	0.002	S1 + S2	0.186	0.000
G1 + G3	0.307	0.000	S1 + S3	0.497	0.000
G1 + G4	0.575	0.000	S1 + S4	0.222	0.000
G2 + G3	0.960	0.000	S2 + S3	0.613	0.024
G2 + G4	0.655	0.000	S2 + S4	0.947	0.000
G3 + G4	0.712	0.194	S3 + S4	0.663	0.000
G1 to G4	F = 0.564	F = 27.354	S1 to S4	F = 0.768	F = 57.077
	P = 0.640	P = 0.000		P = 0.513	P = 0.000

HBsAg: Hepatitis B surface antigen; HPCV: Hepatic parenchyma cell volume; G: Liver inflammation grades; S: Hepatic fibrosis stages.