Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

Table 1 Laboratory result changes in preoperative and postoperative tests

	Preoperative day (day 0)(n = 9)	Postoperative day 7(n = 9)	Postoperative day 14(n = 6)	Postoperative day 21(n = 2)
Aspartate aminotransferase (IU/L)	24.6 ± 14.0	94.3 ± 55.1	46.7 ± 16.9	55.5 ± 2.1
Alanine aminotransferase (IU/L)	64.8 ± 28.8	217.8 ± 94.6	49.7 ± 10.2	94 ± 12.7
Total bilirubin (mmol/L)	0.2 ± 0.1	5.4 ± 3.1	5.7 ± 3.5	5.5 ± 1.5

Data are presented as the mean ± SD.

Table 2 Liver fibrosis grades and perfusion parameters

Fibrosis grades	Grade 1(n = 1)	Grade 2(n = 3)	Grade 3(n = 3)	Grade 4(n = 2)	Odds ratio(95%CI)	P value1
Mean value on the last day
Peak signal intensity (dB)	10.28	10.53 ± 1.53	12.64 ± 0.29	14.35 ± 0.33	1.392 (1.114-1.741)	0.0042
Mean transit time (s)	63.27	49.15 ± 6.7	45.40 ± 5.91	45.78 ± 0.97	0.979 (0.946-1.013)	0.215
Area under the curve (dB s)	1160.84	945.08 ± 196.93	1146.56 ± 39.96	1406.26 ± 3.36	1.001 (1.000-1.003)	0.113
Time to peak (s)	23.18	20.35 ± 3.26	21.85 ± 3.37	27.33 ± 3.39	1.052 (0.959-1.154)	0.284
Mean value difference on the last day and mean value on day 0
Peak signal intensity (dB)	1.63	-0.95 ± 1.1	0.15 ± 1.38	5.2 ± 0.84	1.191 (0.999-1.419)	0.051
Mean transit time (s)	2.78	-4.64 ± 7.67	-14.24 ± 13.21	4.67 ± 0.57	1.001 (0.977-1.026)	0.946
Area under the curve (dB s)	196.26	-272.71 ± 154.65	-259.65 ± 267.88	631.21 ± 92.03	1.001 (1.000-1.002)	0.160
Time to peak (s)	1.6	1.76 ± 4.96	-0.12 ± 3.52	10.42 ± 2.13	1.053 (0.969-1.143)	0.222

¹From generalized estimating equations;

²Statistically significant results were assumed when the P value was less than 0.05. Data are presented as the estimated mean ± SE.