Impact of endoscopic screening on mortality reduction from gastric cancer

Table 1 Target population of the follow-up study

Screening method	Sex	Participants in 2005 (n)	Follow-up
			2006	2007	2008	2009	2010
Endoscopy	Men	6476	6314	6170	6029	5897	5771
	Women	9897	9797	9707	9615	9525	9442
Regular radiography	Men	7019	6841	6683	6548	6384	6246
	Women	11202	11087	10985	10879	10775	10682
Photofluorography	Men	5188	5056	4939	4824	4717	4614
	Women	10739	10638	10545	10450	10357	10270

Table 2 Characteristics of the screening groups n (%)

	Endoscopy	Regular radiography	Photofluorography
Age group
40-49 yr	229 (1.40)	216 (1.19)	1836 (11.53)
50-59 yr	2033 (12.42)	2087 (11.45)	3521 (22.11)
60-69 yr	7880 (48.13)	8568 (47.02)	5830 (36.60)
70-79 yr	6231 (38.06)	7350 (40.34)	4740 (29.76)
Sex
Men	6476 (39.55)	7019 (38.52)	5188 (32.57)
Women	9897 (60.45)	11202 (61.48)	10739 (67.43)

Table 3 Results of gastric cancer screening

Sex	Total number of participants	Cancer detection rate (/1000)	Detected cancers (n)	Deaths from gastric cancer (n)	Deaths from all cancers except gastric cancer (n)	Screening group
All	16373	6.29	103	24	216	Endoscopy
Men	6476	11.12	72	18	154
Women	9897	3.13	31	6	62
All	18221	4.28	78	43	266	Regular radiography
Men	7019	6.70	47	29	173
Women	11202	2.77	31	14	93
All	15927	0.75	12	38	208	Photofluorography
Men	5188	1.93	10	31	130
Women	10739	0.19	2	7	78

Table 4 Comparison of standardized mortality ratio among the screening groups

Reference population	Group		Gastric cancer deaths			All cancer deaths except gastric cancer deaths
			Observed number	Expected number	SMR (95%CI)	Observed number	Expected number	SMR (95%CI)
Niigata city	Endoscopy	Total	24	56	0.43 (0.30-0.57)	216	349	0.62 (0.57-0.67)
		Men	18	37	0.49 (0.32-0.66)	154	220	0.7 (0.64-0.76)
		Women	6	20	0.31 (0.12-0.54)	62	129	0.48 (0.39-0.57)
	Regular radiography	Total	43	63	0.68 (0.55-0.79)	266	393	0.68 (0.63-0.73)
		Men	29	40	0.72 (0.56-0.85)	173	244	0.71 (0.65-0.77)
		Women	14	23	0.62 (0.39-0.80)	93	149	0.62 (0.53-0.70)
	Photofluorography	Total	38	45	0.85 (0.71-0.94)	208	281	0.74 (0.68-0.79)
		Men	31	27	1.13 (1.04-1.43)	130	169	0.77 (0.70-0.83)
		Women	7	17	0.41 (0.18-0.67)	78	112	0.69 (0.59-0.77)
Niigata prefecture	Endoscopy	Total	24	58	0.41 (0.29-0.55)	216	329	0.66 (0.61-0.71)
		Men	18	39	0.47 (0.30-0.63)	154	204	0.75(0.68-0.81)
		Women	6	20	0.3 (0.12-0.54)	62	125	0.5 (0.41-0.59)
	Regular radiography	Total	43	66	0.66 (0.52-0.76)	266	371	0.72 (0.67-0.76)
		Men	29	43	0.68 (0.44-0.75)	173	227	0.76 (0.70-0.82)
		Women	14	23	0.61 (0.39-0.80)	93	144	0.64 (0.56-0.72)
	Photofluorography	Total	38	46	0.83 (0.69-0.92)	208	264	0.79 (0.74-0.84)
		Men	31	29	1.08 (1.01-1.27)	130	157	0.83 (0.76-0.88)
		Women	7	17	0.41 (0.18-0.67)	78	108	0.72 (0.63-0.80)
Japan	Endoscopy	Total	24	54	0.45 (0.31-0.59)	216	357	0.6 (0.55-0.65)
		Men	18	36	0.5 (0.33-0.67)	154	214	0.72 (0.65-0.78)
		Women	6	18	0.34 (0.13-0.59)	62	143	0.43 (0.34-0.51)
	Regular radiography	Total	43	60	0.71 (0.59-0.83)	266	403	0.66 (0.61-0.71)
		Men	29	40	0.73 (0.56-0.85)	173	238	0.73 (0.67-0.79)
		Women	14	21	0.68 (0.43-0.85)	93	165	0.56 (0.48-0.63)
	Photofluorography	Total	38	42	0.9 (0.77-0.97)	208	287	0.73 (0.68-0.78)
		Men	31	27	1.15 (1.04-1.43)	130	164	0.79 (0.72-0.85)
		Women	7	15	0.46 (0.21-0.73)	78	123	0.64 (0.53-0.71)

SMR: Standardized mortality ratio.