Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis

Table 1 Dose adjustment of rapid induction of oral tacrolimus

Trough concentration	< Day 4	Trough concentration	Days 4-14
> 40 ng/mL	0 mg/d	> 40 ng/mL	0 mg/d
25-40 ng/mL	-33%	30-40 ng/mL	-50%
		20-30 ng/mL	-25%
10-25 ng/mL	0%	10-20 ng/mL	0%
< 10 ng/mL	33%	< 10 ng/mL	25%

Table 2 Clinical details of patients

Patients, n	49
Attacks, n	55
Sex, M/F	25/24
Age (mean ± SD)	43.8 ± 16.0
Extent of disease (left sided UC/extensive UC), n	5/44
CAI (mean ± SD)	12.6 ± 3.9
Steroid resistant/dependent, n	38 cases, 42 flare-ups/13 cases, 13 flare-ups

UC: Ulcerative colitis; CAI: Clinical activity index.

Table 3 Adverse responses n (%)

Adverse responses	Value
Hypomagnesemia (< 1.7 mg/dL)	20 (74.1)
Elevated blood glucose (> 120 mg/dL)	18 (48.6)
Tremor	15 (35.7)
Headache	4 (9.5)
Nausea	3 (7.1)
Elevated serum creatinine (> 1.2 mg/dL)	2 (5.4)