Fibroblast growth factor receptor 4 protein expression and clinicopathological features in gastric cancer

Table 1 Correlation of fibroblast growth factor receptor 4 expression with clinicopathological characteristics n (%)

Clinicopathological characteristics	n	FGFR4 positive	FGFR4 negative	χ2	P value
	175	77 (44.00)	98 (56.00)
Gender				0.1140	0.8663
Male	125	56 (44.8)	69 (55.20)
Female	50	21 (42.00)	29 (58.00)
Age (yr)				0.9211	1.0000
< 60	72	32 (44.44)	40 (55.56)
≥ 60	103	45 (43.69)	58 (56.31)
Tumor size				0.1400	0.1518
≤ 3 cm	60	31 (51.67)	29 (48.33)
> 3 cm	115	46 (40.00)	69 (60.00)
Tumor location				1.3942	0.4980
U	32	17 (53.13)	15 (46.88)
M	71	29 (40.85)	42 (59.15)
L	72	31 (43.06)	41 (56.94)
Tumor differentiation				0.2191	0.1129
Poor	76	29 (38.16)	47 (61.84)
Well	99	48 (48.48)	51 (51.52)
Macroscopic type
EGC	21	8 (38.10)	13 (61.90)	9.3842	0.0522
I	9	3 (33.33)	6 (66.67)
II	5	3 (60.00)	2 (40.00)
III	127	62 (48.82)	65 (51.18)
IV	13	1 (7.69)	12 (92.31)
TNM stages				0.3499	0.9504
I	37	15 (40.54)	22 (59.46)
II	45	21 (46.67)	24 (53.33)
III	69	30 (43.48)	39 (56.52)
IV	24	11 (45.83)	13 (54.17)
T				0.9523	0.8128
1	21	8 (38.10)	13 (61.90)
2	29	14 (48.28)	15 (51.72)
3	64	30 (46.88)	34 (53.13)
4	61	25 (40.98)	36 (59.02)
N				1.8160	0.6115
0	55	27 (49.09)	28 (50.91)
1	32	11 (34.38)	21 (65.63)
2	24	11 (45.83)	13 (54.17)
3	64	28 (43.75)	36 (56.25)
M				0.0379	1.0000
0	151	66 (43.71)	85 (56.29)
1	24	11 (45.83)	13 (54.17)
Neural invasion				0.7576	0.5146
Yes	25	9 (36.00)	16 (64.00)
No	150	68 (45.33)	82 (54.67)
Vascular invasion				0.4473	0.2356
Yes	35	13 (37.14)	22 (62.86)
No	140	64 (45.71)	76 (54.29)
P53				3.0941	0.3773
0	72	37 (51.39)	35 (48.61)
1	43	16 (37.21)	27 (62.79)
2	20	7 (35.00)	13 (65.00)
3	40	17 (42.50)	23 (57.50)
P27				0.9924	0.8031
0	87	37 (42.53)	50 (57.47)
1	72	34 (47.22)	38 (52.78)
2	12	4 (33.33)	8 (66.67)
3	4	2 (50.00)	2 (50.00)
Topo IIα				9.4760	0.0236
0	83	29 (34.94)	54 (65.06)
1	66	31 (46.97)	35 (53.03)
2	25	14 (60.87)	9 (39.13)
3	3	3 (100)	0 (0)

FGFR4: Fibroblast growth factor receptor 4; TNM: Tumor-node-metastasis.

Table 2 Relationship between different clinicopathological characteristics and prognosis

Clinicopathological characteristics	FGFR4 positive		FGFR4 negative		χ2	P value
	Median survival time (mo)	5-yr survival rate	Median survival time (mo)	5-yr survival rate
Gender
Male	27	27.4	47	36.7	1.1198	0.2900
Female	43	42.2	46	44.8	0.0000	0.9967
Age (yr)
< 60	31	23.9	35	30.0	0.4080	0.5230
≥ 60	44	36.1	52	46.0	0.6206	0.4308
Tumor size
≤ 3 cm	42	40.4	60	69.0	5.5033	0.0190
> 3 cm	22	24.8	24	26.2	0.0746	0.7848
Tumor location
U	18	31.1	38	31.4	0.7164	0.3973
M	43	31.5	46	38.1	0.0225	0.8807
L	35	29.1	52	42.5	1.1274	0.2883
Tumor differentiation
Poor	17	23.4	35	20.1	2.2622	0.1326
Well	31	47.0	56	62.1	7.9757	0.0047
TNM stages
I + II	56	57.7	60	69.6	1.3128	0.2519
III + IV	15	3.5	19	10.6	0.5328	0.4654
T
T1 + T2	54	55.8	60	82.1	4.8827	0.0271
T3 + T4	22	19.4	18	21.3	0.0479	0.8268
N
N0	58	67.4	60	75.0	0.4856	0.4859
N1 + N2 + N3	18	10.1	25	24.3	2.5385	0.1111
M
0	43	35.3	52	45.4	1.2078	0.2718
1	9	0.0	12	0.0	0.4042	0.5249
Neural I invasion
Yes	19	38.9	56	18.8	2.1949	0.1385
No	36	30.2	49	43.3	3.1118	0.0777
Vascular I invasion
Yes	21	13.8	22	14.3	0.0507	0.8219
No	42	34.0	54	46.2	1.7283	0.1886

FGFR4: Fibroblast growth factor receptor 4; TNM: Tumor-node-metastasis.