Lesion discrimination with breath-hold hepatic diffusion-weighted imaging: A meta-analysis

Table 1 Liver breath-hold diffusion-weighted imaging studies and result

No.	Ref.	MRI unit	Field(T)	Pulse	TR(ms)	TE(ms)	b factors(n)	b factor (Max)	PAT	Acceleration factor	Mean age (yr)	FS	Cutoff (ADC)	Lesion size (mal)
1	Erturk et al[15]	Philips	1.5	SS-SE-EPI	NA	120-125	2	1000	SENSE	2	60.4	Yes	1.63	2.3
2	Ichikawa T et al[16]	Siemens	1.5	SS-SE-EPI	NA	54	3	55	NA	NA	58.0	Yes	5.5	NA
3	Koh et al[18]	Phillips	1.5	SSEPI	1850	56	3	500	SENSE	2	57.0	NA	NA	1.96
4	Löwenthal et al[19]	Phillips	1.5	SSEPI	1850	68	2	500	SENSE	2	61.6	NA	Mal < 2.5 benign > 3	3
5	Taouli et al[20]	Phillips	1.5	SSEPI	2400	104	2	500	NA	NA	52.0	NA	1.5	5
6		Phillips	1.5	SSEPI	3106	104	4	400	NA	NA	52.0	NA	1.5	5
7	Yang et al[1]	Phillips	1.5	SSEPI	1338	66	3	800	SENSE	2	56.0	Yes	NA	1.76
8	Kim et al[17]	GE	1.5	SS-SE-EPI	NA	70	7	846	NA	NA	60.0	Yes	1.6	NA

ADC: Apparent diffusion coefficient; Mal: malignant; NA: Not available; PAT: Parallel acquisition technique; SENSE: Sensitivity encoding; SSEPI: Single-shot echo-planar imaging sequence; SS-SE-EPI: Single-shot spin-echo echo-planar imaging; T: Tesla.

Table 2 Liver breath-hold diffusion-weighted imaging studies and result, n

No.	Ref.	Malignant				Benign						TP	FP	FN	TN
		Total	HCC	Met	Chol	Total	Hem	Cysts	FNH	Ang	Hep
1	Erturk et al[15]	42	21	21	0	44	16	28	0	0	0	40	4	2	40
2	Ichikawa et al[16]	63	48	15	0	11	11	0	0	0	0	59	0	4	11
3	Koh et al[18]	83	0	83	0	50	1	49	0	0	0	65	2.5	18	47.5
4	Löwenthal et al[19]	278	0	278	0	54	24	30	0	0	0	271	15	7	39
5	Taouli et al[20]	24	9	15	0	28	7	6	12	0	3	21	3	4	24
6		24	9	15	0	28	7	6	12	0	3	23	1	6	22
7	Yang et al[1]	51	12	26	13	46	19	27	0	0	0	49	5	2	41
8	Kim et al[17]	49	33	15	1	30	17	12	0	1	0	48	6	1	24

Ang: Angiomyolipoma; Chol: Cholangiocarcinoma; FN: False negative; FNH: Focal nodular hyperplasia; FP: False positive; HCC: Hepatocellular carcinoma; Hem: Hemangioma; Hep: Hepatic adenoma; Met: Metastases; TN: True negative; TP: True positive.