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©The Author(s) 2015.
World J Gastroenterol. Dec 21, 2015; 21(47): 13302-13308
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13302
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13302
Table 1 Characteristics of the 247 patients with rectal neuroendocrine tumor n (%)
Value | |
Age, mean ± SD (range), yr | 51.56 ± 10.69 (27-76) |
Sex | |
Male | 91 (36.8) |
Female | 156 (63.2) |
Tumor size, mean ± SD (mm) | 5.76 ± 2.76 |
Resection type | |
Endoscopic resection | 208 (84.2) |
TEM or TAE | 22 (8.9) |
Radical resection | 16 (6.5) |
None | 1 (0.4) |
Distant organ metastasis at diagnosis | |
Negative | 245 (99.2) |
Positive | 2 (0.8) |
LN metastasis | |
Negative | 232 (93.9) |
Positive | 15 (6.1) |
Table 2 Univariate and multivariate analyses of clinical factors associated with lymph node metastasis in patients with rectal neuroendocrine tumors n (%)
Univariate analysis | Multivariate analysis | ||||
Metastasis (-) | Metastasis (+) | P value | OR (95%CI) | P value | |
Gender | 0.183 | - | - | ||
Male | 144 (92.3) | 12 (7.7) | |||
Female | 88 (96.7) | 3 (3.3) | |||
Age (yr) | 1.000 | - | - | ||
≤ 50 | 113 (94.2) | 7 (5.8) | |||
> 50 | 119 (93.7) | 8 (6.3) | |||
Size (mm) | < 0.001 | 11.53 (2.51-52.93) | 0.002 | ||
< 10 | 219 (98.6) | 3 (1.4) | |||
≥ 10, < 20 | 13 (59.1) | 9 (40.9) | |||
≥ 20 | 0 (0) | 3 (100) | |||
Tumor shape | < 0.001 | - | - | ||
Sessile | 205 (97.6) | 5 (2.4) | |||
Semipedunculated | 27 (77.1) | 8 (22.9) | |||
Ulcerofungating | 0 (0) | 2 (100) | |||
Surface change | < 0.001 | 27.44 (5.96-126.34) | < 0.001 | ||
Smooth | 222 (97.8) | 5 (2.2) | |||
Depressed/eroded | 10 (55.6) | 8 (44.4) | |||
Ulcerated | 0 (0) | 2 (100) | |||
Color | < 0.001 | - | - | ||
Normal or yellow | 210 (96.8) | 7 (3.2) | |||
Hyperemia | 22 (73.3) | 8 (26.7) | |||
Atypical features, any | < 0.001 | 4.38 (0.92-20.80) | 0.064 | ||
Typical features | 189 (98.4) | 3 (1.6) | |||
Atypical features | 43 (78.2) | 12 (21.8) |
Table 3 Atypical features of rectal neuroendocrine tumors according to tumor size n (%)
Typical (n = 192) | Atypical (n = 55) | P value | |
Tumor size (mm) | < 0.001 | ||
< 10 | 186 (83.8) | 36 (16.2) | |
≥ 10, < 20 | 6 (27.3) | 16 (72.7) | |
≥ 20 | 0 (0) | 3 (100) |
Table 4 Association between endoscopic features and metastasis in rectal neuroendocrine tumors < 10 mm and 10-19 mm in diameter n (%)
Metastasis (-) | Metastasis (+) | P value | |
< 10 mm in diameter | |||
Shape | 0.155 | ||
Sessile | 199 (99.0) | 2 (1.0) | |
Semipedunculated | 20 (95.2) | 1 (4.8) | |
Surface change | 0.005 | ||
Smooth | 212 (99.1) | 2 (0.9) | |
Depression/erosion | 7 (87.5) | 1 (12.5) | |
Color | 0.627 | ||
Yellow | 203 (98.5) | 3 (1.5) | |
Hyperemia | 16 (100) | 0 (0) | |
10-19 mm in diameter | |||
Shape | 0.548 | ||
Sessile | 6 (66.7) | 3 (33.3) | |
Semipedunculated | 7 (53.8) | 6 (46.2) | |
Surface change | |||
Smooth | 10 (76.9) | 3 (23.1) | 0.041 |
Depression/erosion | 3 (33.3) | 6 (66.7) | |
Color | 0.665 | ||
Yellow | 7 (63.6) | 4 (36.4) | |
Hyperemia | 6 (54.5) | 5 (45.5) |
Table 5 Association between atypical endoscopic features of rectal neuroendocrine tumors and immunohistochemical staining results n (%)
Typical feature | Atypical feature | P value | |
L-cell | 0.008 | ||
(-) | 27 (62.8) | 16 (37.2) | |
(+) | 142 (81.6) | 32 (18.4) | |
EC-cell | 0.464 | ||
(-) | 162 (78.3) | 45 (21.7) | |
(+) | 7 (70.0) | 3 (30.0) | |
Serotonin | 0.306 | ||
(-) | 161 (78.5) | 44 (21.5) | |
(+) | 8 (66.7) | 4 (33.3) | |
Somatostatin | 1.000 | ||
(-) | 161 (77.8) | 46 (22.2) | |
(+) | 8 (80.0) | 2 (20.0) | |
GLP1 | 0.021 | ||
(-) | 57 (69.5) | 25 (30.5) | |
(+) | 112 (83.0) | 23 (17.0) | |
PYY1 | 0.513 | ||
(-) | 72 (75.8) | 23 (24.2) | |
(+) | 97 (79.5) | 25 (20.5) | |
PPY1 | 0.443 | ||
(-) | 88 (75.9) | 28 (24.1) | |
(+) | 81 (80.2) | 20 (19.8) |
Table 6 Association between atypical features and L-cell type in rectal neuroendocrine tumors n (%)
L-cell (-) | L-cell (+) | P value | |
Tumor shape | 0.107 | ||
Sessile | 34 (18.4) | 151 (81.6) | |
Semipedunculated | 8 (25.8) | 23 (74.2) | |
Ulcerofungating | 1 (100) | 0 (0) | |
Surface change | 0.022 | ||
Smooth | 36 (18.0) | 164 (82.0) | |
Depression/erosion | 6 (37.5) | 10 (62.5) | |
Ulceration | 1 (100) | 0 (0) | |
Color | < 0.001 | ||
Normal or yellow | 31 (16.1) | 162 (83.9) | |
Hyperemia | 12 (50.0) | 12 (50.0) |
- Citation: Hyun JH, Lee SD, Youk EG, Lee JB, Lee EJ, Chang HJ, Sohn DK. Clinical impact of atypical endoscopic features in rectal neuroendocrine tumors. World J Gastroenterol 2015; 21(47): 13302-13308
- URL: https://www.wjgnet.com/1007-9327/full/v21/i47/13302.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i47.13302