Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

doi:10.3748/wjg.v21.i42.12157

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2015; 21(42): 12157-12170
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12157

Table 1 Hepatocellular carcinoma signaling pathways identified by Sleeping Beauty transposon insertional mutagenesis system[63,66]

Pathways	Wnt/Ctnnb1	Trp53	Pi3k-Akt-Mtor	Mapk	Hippo	Tgfb-Bmp	Il6-Stat3	Tnf-Akt¹
Genes involved in corresponding pathways	Lrp1	Prkag2	Insr	Egfr	Fat1	Acvr1	Il6st (gp130)	Tnf
	Lrp5	Ywhaz	Igf1	Met	Wwc1	Acvr2a	Jak1	Egfr
	Lrp6	Crebbp	Pten	Grb2	Taok1	Bmp1	Stat3	Met
	Gsk3b	Mdm2	Pik3ca	Sos1	Taok2	Bmpr1a		Pak4
	Axin1	Usp10	Pik3r1	Sos2	Taok3	Sar1a		Nfib
	Apc	Usp7	Pik3c2a	Kras	Mobkl2b	Tab2		Taok3
	Ctnnb1	Pias1	Pik3ap1	Raf1	Mobkl1a	Tab3		Map2k4
	Tcf7l2	Trp53inp1	Akt2	Map3k1	Sav1	Smad3		Akt
	Csnk1a1	Ppp2r1a	Rps6kb1	Map3k2	Lats1	Smad2		Hif1a
	Csnk1d	Ppp2r2a	Foxo1	Map2k1	Yap1	Smad1		Ube2h
	Csnk1g1	Ppp2r2d		Mapk1	Tead1	Smad4		Qk
	Csnk1g3	Ppp2cb				Smad5		Pi3k
	Tnks	Ppp2r5e						Jnk
	Tnks2	Trp53

¹Indicates a network.

Citation: Chiu AP, Tschida BR, Lo LH, Moriarity BS, Rowlands DK, Largaespada DA, Keng VW. Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12157-12170
URL: https://www.wjgnet.com/1007-9327/full/v21/i42/12157.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i42.12157