Gastroenterologist perceptions of faecal microbiota transplantation

Table 1 Gastroenterologist “faecal microbiota transplantation” perceptions survey

Gastroenterologist “faecal microbiota transplantation” (fmt) perceptions survey
1: How would you best describe yourself? (may select more than one option)
a: General Gastroenterologist
b: Hepatology subspecialist
c: Inflammatory Bowel Disease subspecialist
d: Advanced/Therapeutic endoscopy subspecialist
e: Gastroenterology trainee
f: Other; please describe in space below
2: What is the nature of your practice/work? (may select more than one option)
a: Staff Specialist
b: Public Hospital Visiting Medical Officer
c: Private Practice
d: > 40% Medical Research
e: Other; please describe in space below
3: Have you been consulted by a patient who has had FMT before? If yes please circle the indication for the FMT (may select more than one option)
a. No
b: Clostridium difficile
c: Ulcerative Colitis
d: Crohn’s disease
e: Irritable bowel syndrome
f: Other; please describe in space below
4: Have you ever referred a patient for FMT before?
a: Yes – please elaborate in space below (indication, number of referrals, outcome)
b: No
5: Please select which of the following indications, if any, you would consider referring for FMT if easily available (may select more than one option)
a: Clostridium difficile
b: Ulcerative Colitis
c: Crohn’s disease
d: Irritable bowel syndrome
e: Other; please list in space below
f: I would not consider referring for FMT for any indication
6: If a patient saw you and expressed interest in undergoing FMT would you (you may select more than one option)
a: Advise against it
b: Remain ambivalent
c: Acknowledge their interest and refer them for FMT
d: Only refer them for FMT for the indication of recurrent Clostridium difficile
e: Suggest they only participate in clinical trials involving FMT
f: Other; please describe in space below
7: Please select your response in answer to each of the following potential concerns with FMT
a: I don’t believe in FMT and I don’t think it is an effective therapy
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
b: While FMT may work at present there is inadequate evidence for efficacy
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
c: There is a significant infection risk from donor stool despite screening
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
d: I have other safety concerns regarding non-infectious adverse reactions with FMT
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
e: There is a risk of disease exacerbation with FMT
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
f: I don’t think my patients would contemplate or consent to FMT
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
g: “Yuck” factor (Aesthetics)
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
h: Lack of availability/accessibility to FMT
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
i: Other; please describe in space below
8: What is your greatest concern, if any, regarding FMT? Please select only one
a: Lack of efficacy
b: Lack of evidence
c: Infection risk from donor stool despite screening
d: Non infectious adverse reaction and lack of safety data
e: Possible disease exacerbation
f: “Yuck” factor of donor stool
g: None; I have no concerns regarding FMT
h: Other; please list in space below
9: How do you feel the potential risks of FMT compare with blood transfusion or other biologic product administration?
a: More risk with blood transfusion than FMT
b: More risk with FMT than blood transfusion
c: Not sure
d: Other; please describe in space below
10: What do you think is the optimal modality through which to deliver FMT?
a: Transcolonoscopic
b: Enema based
c: Nasoduodenal/jejunal
d: Other; please list in space below
e: I don’t have an opinion
11: If your patient had exhausted all other medical options and was facing surgery for refractory disease in which FMT has been suggested as a potential therapeutic option, would you consider FMT as a last resort therapy?
a: Yes
b: Yes but only for Clostridium difficile
c: Yes but only in a clinical trial
d: Not sure
e: No
f: Other; please describe in space below
12: Do you think FMT holds promise as a potential future therapy for certain gastrointestinal diseases?
a: Yes
b: No
c: Not Sure
d: Other; please describe in space below
13: Would you be willing to enroll your patients in clinical trials assessing FMT?
a: Yes
b: No
c: Not Sure
d: Other; please describe in space below
14: In the next 3 yr, do you foresee a situation where you would consider referring a patient for FMT outside a clinical trial if a trusted service was available? Please select your answer for each of the following indications
a. No, I would not consider referring for FMT for any indication
b: Recurrent Clostridium difficile infection
Highly Likely	Somewhat Likely	Somewhat Unlikely	Highly unlikely
c: Ulcerative Colitis
Highly Likely	Somewhat Likely	Somewhat Unlikely	Highly unlikely
d: Crohn’s disease
Highly Likely	Somewhat Likely	Somewhat Unlikely	Highly unlikely
e: Irritable bowel syndrome or other functional gut disorder
Highly Likely	Somewhat Likely	Somewhat Unlikely	Highly unlikely
15: With regards to FMT, please select your response to the following statements
a: I already offer FMT as a therapeutic option in my practice
b: I have an interest in learning how to process and administer FMT so that I or my institution can arrange such therapy for our patients independently
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
c: I believe a few select centres that satisfy appropriate regulatory requirements should be available in my city to offer FMT
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
d: I don’t believe the therapy should be available for routine clinical use
Strongly Disagree	Somewhat Disagree	Somewhat Agree	Strongly Agree
16: After reviewing the attached FOCUS study letter of invitation, protocol summary and selection criteria
a: Are you likely to refer patients who meet selection criteria to this study?
Highly Likely	Somewhat Likely	Somewhat Unlikely	Highly unlikely
b: Do you have any actual patients in mind that you would consider referring to this study?
Highly Likely	Somewhat Likely	Somewhat Unlikely	Highly unlikely
17: Any other comments regarding FMT that you wish to make?