Platelet count combined with right liver volume and spleen volume measured by magnetic resonance imaging for identifying cirrhosis and esophageal varices

Table 1 The main clinical characteristics of healthy volunteers and cirrhotic patients with different modified Child-Pugh classes

Variable	Healthy volunteers	Cirrhotic patients (n = 205)			P value
	(n = 40)	Class A (n = 47)	Class B (n = 95)	Class C (n = 63)
Gender (M/F)	24/16	24/23	60/35	43/20	0.816
Age (yr)	51.50 ± 2.31	58.13 ± 1.83	55.99 ± 1.18	54.38 ± 1.63	0.056
Esophageal varices	Not appear	17.02% (8/47)	45.26% (43/95)1	58.73% (37/63)1	< 0.001a
PLT (109/L)	249.70 ± 5.71	178.29 ± 12.77	137.67 ± 22.171	82.44 ± 21.1412	< 0.001a
SV/PLT	0.56 ± 0.03	1.98 ± 0.25	5.23 ± 1.051	29.50 ± 13.5512	< 0.001a
SI/PLT	1.15 ± 0.06	4.07 ± 0.49	11.77 ± 2.081	67.39 ± 24.9112	< 0.001a
RVPS	1898.72 ± 138.12	686.34 ± 121.37	359.99 ± 41.371	80.06 ± 10.1012	< 0.001a

¹Different from Child-Pugh class A;

²Different from Child-Pugh class B, and all the comparisons denote significance after Bonferroni correction (P < 0.05).

^aP value shows the difference between cirrhotic patients and healthy volunteers. BMI: Body mass index; SV: Spleen volume; SI: Spleen volumetric index; PLT: Platelet count; RV: Right liver lobe volume; RVPS: RV × PLT/SV; M: Male; F: Female.

Table 2 Comparison of the parameters between cirrhotic patients with and without esophageal varices

Parameter	Esophageal varices		P value
	No (n = 117)	Yes (n = 88)
PLT (109/L)	142.98 ± 81.45	99.33 ± 73.72	< 0.001
SV/PLT	4.22 ± 5.98	14.58 ± 20.62	< 0.001
SI/PLT	11.40 ± 16.73	48.33 ± 131.01	< 0.001
RVPS	494.72 ± 650.52	160.62 ± 171.01	< 0.001

PLT: Platelet count; SV: Spleen volume; SI: Spleen volumetric index; RV: Right liver lobe volume; RVPS: RV × PLT/SV.

Table 3 Receiver operating curve analysis of measured parameters for identifying the presence and Child-Pugh class of cirrhosis, and the presence of esophageal varices

Parameter	Cutoff values	Differentiations	AUC	Sensitivity	Specificity
PLT (109/L)	217	Normal liver vs cirrhosis	0.903	97.5%	86.8%
	140	Child-Pugh class A vs B	0.661	66.0%	64.2%
	114	Child-Pugh class A vs C	0.859	80.9%	82.5%
	96.5	Child-Pugh class B vs C	0.703	61.1%	79.4%
	99.5	No varices vs varices	0.678	61.5%	60.2%
SV/PLT	0.83	Normal liver vs cirrhosis	0.952	91.2%	97.5%
	2.99	Child-Pugh class A vs B	0.663	58.9%	63.8%
	5.19	Child-Pugh class A vs C	0.873	69.8%	95.7%
	5.40	Child-Pugh class B vs C	0.722	69.8%	62.1%
	4.13	No varices vs varices	0.782	72.7%	68.4%
SI/PLT	2	Normal liver vs cirrhosis	0.967	93.7%	97.5%
	6.08	Child-Pugh class A vs B	0.692	65.3%	61.7%
	12.55	Child-Pugh class A vs C	0.902	76.2%	97.9%
	13.01	Child-Pugh class B vs C	0.724	74.6%	63.2%
	11.08	No varices vs varices	0.773	72.7%	70.1%
RVPS	883.90	Normal liver vs cirrhosis	0.973	97.5%	92.7%
	330.98	Child-Pugh class A vs B	0.740	78.7%	62.1%
	175.72	Child-Pugh class A vs C	0.976	93.6%	92.1%
	129.36	Child-Pugh class B vs C	0.853	72.6%	81.0%
	226.46	No varices vs varices	0.758	64.1%	79.5%

PLT: Platelet count; SV: Spleen volume; SI: Spleen volumetric index; RV: Right liver lobe volume; RVPS: RV × PLT/SV; AUC: Area under the receiver operating curve.