Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions

Table 1 Microscopy findings of the liver in female spontaneously diabetic Torii fatty rats and Sprague-Dawley rats

	8 wk		16 wk		24 wk		32 wk		40 wk
	SD	SDT fatty	SD	SDT fatty	SD	SDT fatty	SD	SDT fatty	SD	SDT fatty
Hepatosteatosis (Vacuolar change/fatty change)
-	5	0	5	0	5	0	5	0	5	0
±	0	0	0	0	0	0	0	0	0	0
+	0	0	0	0	0	0	0	0	0	0
2+	0	4	0	2	0	2	0	3	0	3
3+	0	1	0	3	0	2	0	2	0	2
Hypertrophy of hepatocytes (with vacuolation/fatty change)
-	5	1	5	0	5	0	5	0	5	1
±	0	0	0	0	0	0	0	0	0	0
+	0	2	0	2	0	2	0	1	0	2
2+	0	2	0	3	0	2	0	3	0	1
3+	0	0	0	0	0	0	0	1	0	1
Fibrosis, focal
-	5	4	5	5	5	4	5	1	5	1
±	0	0	0	0	0	0	0	0	0	0
+	0	1	0	0	0	0	0	1	0	2
2+	0	0	0	0	0	0	0	3	0	2
3+	0	0	0	0	0	0	0	0	0	0
Infiltration, inflammatory cell, periportal
-	5	2	5	4	5	3	5	3	5	3
±	0	3	0	1	0	1	0	0	0	1
+	0	0	0	0	0	0	0	2	0	1
2+	0	0	0	0	0	0	0	0	0	0
3+	0	0	0	0	0	0	0	0	0	0