Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma

Table 1 Targeting hepatocellular carcinoma related gene products

No.	Approach	Molecular target	In vivo model	Effects	Ref.
1	Targeting molecules more relevant for HCC than normal liver	Integrins	Mouse genetically induced HCC	Reduction HCC cell proliferation	20
2	Targeting molecules overexpressed in HCC tissue	ECT2	Mouse xenograft HCC	Reduction HCC cell proliferation	21
3	Targeting molecules overexpressed in HCC tissue	CDK9	Mouse orthotopic HCC	Reduction HCC cell proliferation	22
4	Targeting molecules overexpressed in HCC tissue	ISG15	Mouse xenograft HCC	Reduction HCC cell proliferation	23
5	Targeting of genes causing drug resistance	Mapk14	Mouse genetically induced HCC	Increased sorafenib sensitivity	24
6	Targeting of genes causing drug resistance	Aurora-A	Mouse xenograft HCC	Increased adriamycin and cisplatin sensitivity	25

HCC: Hepatocellular carcinoma.

Table 2 Delivery systems for short RNAs

No.	Approach	Molecular target	In vivo model	Effects	Ref.
1	PEI-GAL nano particles	ApoB	Normal mouse liver	Healthy liver targeting	26
2	PHEA-DEAEMA	E2F1	-	HCC cell in vitro targeting	27
3	Inu-DETA	E2F1	-	HCC cell in vitro targeting	29
4	Lipid-PEG	FVII	Normal mouse liver	Healthy liver targeting	31
5	pH-sensitive lipids	miRNA 122	Normal mouse liver	Healthy liver targeting	32
6	US sensible lipids	BCL-2	Mouse Xenograft HCC	HCC targeting	33

PEI: Polyethyleneimine; DEAEMA: Diethylamino ethyl methacrylate; miRNA: Micro interfering RNA; HCC: Hepatocellular carcinoma.