Association of nonalcoholic fatty liver disease and liver cancer

doi:10.3748/wjg.v21.i3.913

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2015; 21(3): 913-918
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.913

Table 1 Neoplasms of 120 patients with primary and secondary hepatic neoplasm n (%)

Neoplasms	Incidence rate	Age, yr	Sex (male)	Steatosis	Fibrosis	NASH
NCLM	48 (40.0)	56.9	19 (39.6)	11 (22.9)	24 (50.0)	2 (4.2)
LMCC	40 (33.3)	57.5	25 (62.5)	22 (55.0)	15 (37.5)	0 (0.0)
HCC	16 (13.3)	57.9	13 (81.3)	4 (25.0)	12 (75.0)	0 (0.0)
IHCC	11 (9.2 )	63.3	2 (18.2)	3 (27.3)	7 (63.6)	0 (0.0)
Others	5 (4.2)	64.4	0 (0.0)	1 (20.0)	2 (40.0)	0 (0.0)

HCC: Hepatocellular carcinoma; IHCC: Intrahepatic cholangiocarcinoma; LMCC: Liver metastasis of colorectal cancer; NASH: Nonalcoholic steatohepatitis; NCLM: Non-colorectal liver metastasis; Others: Lymphoproliferative tumors and sarcoma.

Table 2 Association of risk factors for nonalcoholic fatty liver disease with steatosis and liver fibrosis in 120 patients with primary and secondary hepatic neoplasm

NAFLD riskfactor (n)	Liver steatosis			Liver fibrosis
NAFLD riskfactor (n)	n (%)	P value	OR (95%CI)	n (%)	P value	OR (95%CI)
GI and/or DM (41)	14 (34.1)	0.182	1.70 (0.78 -3.71)	31 (51.7)	0.196	0.62 (0.30-1.28)
Dyslipidemia (17)	9 (52.9)	0.078	2.50 (0.88-7.06)	8 (47.1)	0.793	0.87 (0.31-2.44)
Hypertension (55)	24 (43.6)	< 0.001¹	3.99 (1.73-9.16)	31 (56.4)	0.200	1.60 (0.78-3.31)
Overweight (53)	26 (49.1)	0.002	3.76 (1.56-9.05)	30 (56.6)	0.165	1.74 (0.79-3.81)

¹A statistically significant difference. DM: Diabetes mellitus; GI: Glucose intolerance; NAFLD: Nonalcoholic fatty liver disease.

Table 3 Prevalence of steatosis and hepatic fibrosis according to type of hepatic neoplasm

Histologic type (n)	Liver steatosis			Liver fibrosis
Histologic type (n)	n (%)	P value	OR (95%CI)	n (%)	P value	OR (95%CI)
LMCC (40)	22 (55.0)	< 0.001¹	3.99 (1.78-8.94)	15 (37.5)	0.053	0.47 (0.21-1.02)
NCLM (48)	11 (22.9)	0.034	0.42 (0.18-0.95)	24 (50.0)	1.000	1.00 (0.48-2.08)
HCC (16)	4 (25.0)	0.406	0.60 (0.18-2.01)	12 (75.0)	0.032¹	3.50 (1.06-11.57)
IHCC (11)	3 (27.3)	0.613	0.70 (0.18-2.80)	7 (63.6)	0.343	1.85 (0.51-6.68)

¹A statistically significant difference. HCC: Hepatocellular carcinoma; IHCC: Intrahepatic cholangiocarcinoma; LMCC: Liver metastasis of colorectal cancer; NCLM: Non-colorectal liver metastasis.

Citation: Schulz PO, Ferreira FG, Nascimento MFA, Vieira A, Ribeiro MA, David AI, Szutan LA. Association of nonalcoholic fatty liver disease and liver cancer. World J Gastroenterol 2015; 21(3): 913-918
URL: https://www.wjgnet.com/1007-9327/full/v21/i3/913.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i3.913