Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection

Table 1 Characteristics of our 5 cases

	Case 1	Case 2	Case 3	Case 4	Case 5
Age (yr)/sex	78/Female	74/Male	67/Male	72/Male	70/Female
Serum anti-H. pylori antibody	Negative	Negative	Negative	Negative	Negative
Chronic gastritis	Antral gastritis	(-)	(-)	(-)	(-)
Location	Upper/Ant	Upper/Gre	Upper/Gre	Upper/Gre	Upper/Post
Size (mm)	13	5	8	5	8
Macroscopic feature	IIa	IIa	IIa	IIb	IIa
Microvascular pattern on NBI-ME	Irregular	Irregular	Regular	Regular	Regular
Endoscopic diagnosis	Adenocarcinoma	SMT	Carcinoid	GA-FG	Adenocarcinoma
Histological classification	tubular	tubular	tubular	tubular	tubular
Depth	SM (700 μm)	SM (80 μm)	SM (980 μm)	SM (110 μm)	SM (1230 μm)
Lymphatic/venous invasion	(+)/(-)	(-)/(-)	(-)/(-)	(-)/(-)	(-)/(-)
MUC2/MUC5AC/MUC6/Pepsinogen-I	(-)/(-)/(+)/(+)	(-)/(-)/(+)/(+)	(-)/(-)/(+)/(+)	(-)/(-)/(+)/(+)	(-)/(-)/(+)/(+)
p53/Ki-67 labeling index	(-)/Low	(-)/Low	(-)/Low	(-)/Low	(-)/Low

IIa: Elevated lesion; IIb: Flat lesion; Ant: Anterior wall; GA-FG: Gastric adenocarcinoma of fundic gland type; Gre: Greater curvature; NBI-ME: Narrow-band imaging with magnifying endoscopy; Post: Posterior wall; SM: Submucosal layer; SMT: Submucosal tumor.

Table 2 Clinicopathological findings of previous and present cases

Reports	[4]	[5,8]	[9]	[10]	[11]	[12]	[13]	Present cases
Number of patients	1	25 (27 lesions)	1	1	1	1	10	5
Age (yr)	82	67 (average)	59	56	50s	71	64.2 (average)	72.2 (average)
Sex (Male:Female)	Female	16:9	Female	Male	Male	Female	4:6	3:2
Therapy	EMR	Operation: 3	ESD	EAM	ESD	EMR	polypectomy	ESD
		ESD or EMR: 7
		ND: 15
Location (Upper:Middle:Lower)	Upper	23:4:0	Upper	Upper	Middle	Upper	10:0:0	5:0:0
Size (average, mm)	16	12.2 (3-42)	8	5	42	ND	4.3	7.8 (5-13)
Macroscopic feature (I:IIa:IIb:IIc:IIa + IIc)	I (protrude)	1:14:2:8:2	IIb	IIa	IIa + IIc	IIa	10:0:0:0:0	0:4:1:0:0
Depth (M:SM)	M	6:21	SM	SM	SM	SM	10:00	0:05
Lymphatic/venous	(-)/(-)	2/1	(-)/(-)	(-)/(-)	(-)/(-)	(-)/(-)	0/0	1/0
invasion
Survival time (average, mo)	ND	27 (10-70)	17	12	ND	12	15 (6-39)	10.6 (2-20)
Outcome	ND	NED: 10	NED	NED	ND	NED	NED: 8	NED:5
		ND: 15					Persistence: 1
							ND: 1

EAM: Endoscopic aspiration mucosectomy; EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; M: Mucosal; ND: Not described; NED: No evidence of disease; SM: Submucosal.