Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation

Table 1 Effect of losartan administration in liver injury after orthotopic liver transplantation

	Sham	ROLT	Losartan + ROLT
ALT (U/L)	48.8 ± 2.58	358.3 ± 133.44a	206.00 ± 33.61ab
AST (U/L)	88.2 ± 4.65	893.57 ± 397.69a	500.85 ± 118.07ab

Alanine aminotransferase (ALT) levels and aspartate aminotransferase (AST) in plasma after 24 h of reperfusion.

^aP < 0.05 vs Sham,

^bP < 0.05 vs ROLT. Sham: liver harvested without transplantation; ROLT: Liver subjected to reduced-size orthotopic liver transplantation after 1 h of cold storage in University of Wisconsin solution; losartan + ROLT: Same as ROLT group, but with further administration of losartan 24 h and 1 h before the surgical procedure to both the donor and the recipient.