Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma

doi:10.3748/wjg.v21.i20.6317

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2015; 21(20): 6317-6328
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6317

Table 1 CTNNB1 mutation case resources in each article

PubMed ID	Total cases	HBV infection cases	HCV infection cases	HBV and HCV coinfection cases	Non-viral infection cases
9635572	14/75	NA/NA	NA/NA	NA/NA	NA/NA
9671767	8/31	NA/NA	NA/NA	NA/NA	NA/NA
10487827	14/32	2/5	2/13	0/0	10/13
10595907	13/22	0/0	13/22	0/0	0/0
10665646	9/38	NA/NA	NA/NA	NA/NA	NA/NA
10700176	13/100	NA/NA	NA/NA	NA/NA	NA/NA
10980116	57/421	27/265	23/95	3/44	4/17
11282485	6/32	NA/NA	NA/NA	NA/NA	NA/NA
11375957	26/137	3/33	12/31	0/9	11/41
11429783	0/22	0/0	0/0	0/0	0/22
11443619	7/60	5/48	0/2	0/0	2/10
11477549	1/14	0/1	1/12	0/0	0/1
11570580	15/34	NA/NA	NA/NA	NA/NA	NA/NA
12101426	14/73	NA/NA	NA/NA	NA/NA	NA/NA
12375019	10/57	0/0	10/57	0/0	0/0
12439747	184/1123	NA/NA	NA/NA	NA/NA	NA/NA
12845670	24/100	5/26	16/51	0/0	3/23
14999698	3/61	0/29	0/7	0/1	0/0
15067328	10/89	NA/NA	NA/NA	NA/NA	NA/NA
15151624	1/61	NA/NA	NA/NA	NA/NA	NA/NA
15288479	2/16	0/0	0/4	0/0	2/6
15305374	44/781	NA/512	NA/151	NA/52	NA/66
15814635	37/265	NA/161	NA/53	NA/26	NA/25
17187432	34/120	NA/NA	NA/NA	NA/NA	NA/NA
17393110	7/29	NA/NA	NA/NA	NA/NA	NA/NA
17510384	13/81	2/13	8/44	1/2	2/18
17531558	4/42	0/7	4/23	0/3	0/9
18171349	1/36	0/21	0/4	0/0	1/11
18282277	11/52	NA/NA	NA/NA	NA/NA	NA/NA
18358501	4/54	3/43	0/1	0/2	1/8
18467159	47/223	NA/NA	NA/NA	NA/NA	NA/NA
18701503	28/81	0/0	28/81	0/0	0/0
19101982	10/32	0/0	3/6	0/0	7/26
20347502	1/1	0/0	1/1	0/0	0/0
20923573	7/15	1/4	4/10	0/0	2/2
20963515	2/20	2/20	0/0	0/0	0/0
21457159	19/44	3/11	10/23	1/2	5/8
21822264	28/139	5/50	13/43	1/2	9/44
22561517	42/149	3/32	7/24	1/4	31/89
25021421	53/176	13/78	NA/NA	NA/NA	NA/NA

Data are presented as the number of mutation cases/category total. HBV: Hepatitis B virus; HCV: Hepatitis C virus; NA: Not available.

Table 2 AXIN1 mutation case resources in each article

PubMed ID	Total cases	HBV infection cases	HCV infection cases	HBV and HCV coinfection cases	Non-viral infection cases
10700176	9/100	NA/NA	NA/NA	NA/NA	NA/NA
11375957	12/112	8/32	0/31	2/9	2/40
12101426	4/56	0/9	0/5	0/2	4/40
15067328	25/89	NA/NA	NA/NA	NA/NA	NA/NA
18171349	9/36	5/21	3/4	0/0	1/11
21499249	1/1	0/0	1/1	0/0	0/0
22561517	19/149	5/32	5/24	1/4	8/89
25021421	25/176	13/78	NA/NA	NA/NA	NA/NA

Data are presented as the number of mutation cases/category total. HBV: Hepatitis B virus; HCV: Hepatitis C virus; NA: Not available.

Table 3 TP53 mutation case resources in each article

PubMed ID	Total cases	HBV infection cases	HCV infection cases	HBV and HCV coinfection cases	Non-viral infection cases
1311638	0/21/36	0/21/36	0/0/0	0/0/0	0/0/0
1327523	3/20/61	3/12/37	0/4/17	0/3/4	0/1/3
1655254	2/9/43	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
1672732	0/5/10	0/5/8	0/0/NA	0/0/NA	0/0/NA
1849234	0/8/16	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
7903205	2/20/35	2/15/28	0/NA/NA	0/NA/NA	0/NA/NA
8093350	1/17/53	0/3/7	NA/NA/NA	NA/NA/NA	NA/NA/NA
8093978	0/3/20	0/NA/17	0/NA/NA	0/NA/NA	0/NA/NA
8100480	1/3/20	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
8108145	2/6/15	2/6/15	0/0/0	0/0/0	0/0/0
8261444	5/12/16	1/2/3	4/8/10	0/1/2	0/1/1
8290606	0/19/80	0/8/28	0/NA/NA	0/NA/NA	0/NA/NA
8302580	1/6/22	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
8380058	0/2/15	0/NA/NA	0/NA/NA	0/NA/NA	0/NA/NA
8382111	0/12/38	0/NA/NA	0/NA/NA	0/NA/NA	0/NA/NA
8384081	0/4/45	0/4/28	0/0/11	0/0/2	0/0/4
8389246	0/11/34	0/NA/NA	0/NA/NA	0/NA/NA	0/NA/NA
8390289	0/10/15	0/8/13	0/NA/NA	0/NA/NA	0/NA/NA
8390407	0/1/18	0/0/3	0/0/5	0/0/1	0/1/9
8393166	1/1/7	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
8407553	3/19/63	2/10/16	1/4/15	0/0/0	0/5/32
8565124	0/2/12	0/0/3	0/0/2	0/0/1	0/2/6
8655704	3/10/38	NA/NA/19	NA/NA/10	NA/NA/5	NA/NA/4
8655958	2/2/20	1/1/4	NA/NA/NA	NA/NA/NA	NA/NA/NA
8672994	0/1/18	0/NA/NA	0/NA/NA	0/NA/NA	0/NA/NA
8895490	0/9/12	0/0/0	0/1/3	0/2/3	0/3/6
9012469	0/8/16	0/1/8	0/NA/NA	0/NA/NA	0/NA/NA
9270015	2/26/105	2/24/78	0/NA/NA	0/NA/NA	0/NA/NA
9463584	0/2/8	0/NA/NA	0/NA/NA	0/NA/NA	0/NA/NA
9699537	2/6/97	NA/NA/16	NA/NA/NA	NA/NA/NA	NA/NA/NA
9781942	1/2/15	0/0/0	1/2/15	0/0/0	0/0/0
10389750	0/17/31	0/11/17	0/NA/NA	0/NA/NA	0/NA/NA
10389978	0/12/24	0/10/19	0/NA/NA	0/NA/NA	0/NA/NA
10564952	2/9/11	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
10662591	0/5/27	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
10699891	4/11/18	0/0/0	0/0/0	0/0/0	4/11/18
10743047	0/35/40	0/33/38	0/NA/NA	0/NA/NA	0/NA/NA
11051249	2/21/83	0/14/50	1/6/16	0/0/0	1/1/17
11191353	0/14/55	0/NA/45	0/NA/NA	0/NA/NA	0/NA/NA
11282486	2/6/22	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
11375957	1/36/137	1/15/33	0/10/31	0/3/9	0/8/41
11704835	8/30/71	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
12483005	3/7/34	2/5/27	0/1/3	0/0/0	1/1/4
12640682	0/2/18	0/1/5	0/1/8	0/0/4	0/0/1
12759240	2/16/33	2/16/33	0/0/0	0/0/0	0/0/0
12845670	0/14/100	0/4/26	0/7/51	0/0/0	0/3/23
14499690	0/18/68	0/NA/52	0/NA/2	0/0/0	0/NA/14
14675778	0/5/22	0/0/0	0/5/22	0/0/0	0/0/0
14687797	3/9/80	2/7/NA	0/1/NA	0/0/NA	1/1/NA
15017592	4/22/50	NA/NA/13	NA/NA/33	NA/NA/3	NA/NA/1
15126338	3/27/48	NA/NA/NA	NA/NA/NA	NA/NA/NA	NA/NA/NA
15943041	8/8/20	8/8/20	0/0/0	0/0/0	0/0/0
16078640	2/7/41	NA/NA/1	NA/NA/26	NA/NA/NA	NA/NA/NA
16570275	1/11/40	1/4/22	0/2/5	0/2/5	0/3/8
16685387	0/28/55	0/NA/49	0/NA/NA	0/NA/NA	0/NA/NA
16697535	0/7/23	0/7/23	0/0/0	0/0/0	0/0/0
17066440	0/5/51	0/0/14	0/4/30	0/0/0	0/1/7
17266182	1/28/50	1/24/41	0/NA/NA	0/NA/NA	0/NA/NA
17350822	4/16/83	NA/2/13	NA/13/64	NA/0/2	NA/1/4
17510384	0/25/81	0/5/13	0/15/44	0/2/2	0/3/18
17531558	2/7/42	1/1/7	1/4/24	0/1/2	0/1/9
21499249	0/1/1	0/0/0	0/1/1	0/0/0	0/0/0
21760996	0/9/26	0/6/13	0/2/4	0/0/0	0/0/4
21822264	4/39/139	2/20/50	1/10/43	0/2/2	1/7/44
22561517	0/26/149	0/9/32	0/7/24	0/2/4	0/8/89
22634756	3/14/27	3/7/11	0/7/14	0/0/0	0/0/2
22922871	1/1/10	1/1/10	0/0/0	0/0/0	0/0/0

Data are presented as the number of gain-of-function mutation cases/number of mutations/category total. HBV: Hepatitis B virus; HCV: Hepatitis C virus; NA: Not available.

Table 4 Mutation case numbers and rates of CTNNB1 in different tissues

Cancer type	Mutation cases (n)	Total cases (n)	Mutation rate (%)	P value¹
HCC	671	3720	18.04
Colon Adenocarcinoma	126	1318	9.56	< 0.001
Ovary carcinoma	102	1599	6.38	< 0.001
Stomach Adenocarcinoma	54	1137	4.75	< 0.001
Lung Adenocarcinoma	38	1219	3.12	< 0.001
ESCC	5	347	1.44	< 0.001

¹The P value vs HCC. ESCC: Esophageal squamous cell carcinoma; HCC: Hepatocellular carcinoma.

Table 5 Mutation case numbers and rates of CTNNB1 in hepatocellular carcinoma etiologies

Viral background	Mutation cases (n)	Total cases (n)	Mutation rate (%)	P value¹
HBV	74	686	10.79
HCV	155	554	27.98	< 0.001
HBV and HCV	7	69	10.14	0.999
Non-viral	90	348	25.86	< 0.001

¹The P value vs HBV. HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 6 Mutation case numbers and rates of AXIN1 in different tissues

Cancer type	Mutation cases (n)	Total cases (n)	Mutation rate (%)
Hepatocellular carcinoma	75	872	8.60
Colon adenocarcinoma	20	513	3.90
Ovary carcinoma	3	749	0.40
Stomach adenocarcinoma	18	377	4.77
Lung adenocarcinoma	6	697	0.86
Esophageal squamous cell carcinoma	3	130	2.31

Table 7 Mutation case numbers and rates of AXIN1 in hepatocellular carcinoma etiologies

Viral background	Mutation cases (n)	Total cases (n)	Mutation rate (%)	P value¹
HBV	31	172	18.02
HCV	9	65	13.85	0.964
HBV and HCV	3	15	20.00	0.999
non-viral	15	180	8.33	0.122

¹The P value vs HBV. HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 8 Mutation case numbers and rates of TP53 in different tissues

Cancer type	GOF mutation cases (n)	Mutation cases (n)	Total cases (n)	GOF mutation rate (%)	Non-GOF mutation rate (%)	Total mutation rate (%)	P value¹
HCC	91	825	2813	3.23	26.09	29.33
Colon adenocarcinoma	331	1867	3596	9.20	42.71	51.92	< 0.001
Ovary carcinoma	392	1604	3329	11.78	36.41	48.18	< 0.001
Stomach adenocarcinoma	270	1160	3459	7.81	25.73	33.54	< 0.001
Lung adenocarcinoma	421	2414	6394	6.58	31.17	37.75	< 0.001
ESCC	224	972	1858	12.06	40.26	52.31	< 0.001

¹GOF mutation rate vs HCC. ESCC: Esophageal squamous cell carcinoma; GOF: Gain-of-function; HCC: Hepatocellular carcinoma.

Table 9 Mutation case numbers and rates of TP53 in hepatocellular carcinoma etiologies

Viral background	GOF mutation cases (n)	Mutation cases (n)	Total cases (n)	GOF mutation rate (%)	Non-GOF mutation rate (%)	Total mutation rate (%)
HBV	35	321	819	4.27	34.92	39.19
HCV	9	101	398	2.26	23.12	25.38
HBV and HCV	0	18	41	0.00	43.90	43.90
non-viral	7	60	346	2.02	15.32	17.34

GOF: Gain-of-function; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Citation: Ding SL, Yang ZW, Wang J, Zhang XL, Chen XM, Lu FM. Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol 2015; 21(20): 6317-6328
URL: https://www.wjgnet.com/1007-9327/full/v21/i20/6317.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i20.6317