Expression of COX-2 and HER-2 in colorectal cancer and their correlation

Table 1 Relationship between COX-2/HER-2 expression and clinicopathologic factors n (%)

Variable	n	COX-2				HER-2
		Positive	Negative	χ2	P value	Positive	Negative	χ2	P value
Sex				2.300	0.129			2.769	0.096
Male	595	454 (76.3)	62 (20.0)			288 (48.4)	307 (51.6)
Female	431	346 (80.2)	32 (15.1)			186 (43.2)	245 (56.8)
Age (yr)				2.011	0.156			1.496	0.221
< 60	493	375 (76.1)	40 (16.3)			218 (44.2)	275 (55.8)
≥ 60	533	425 (79.7)	54 (19.6)			256 (48.0)	277 (52.0)
Tumor site				2.007	0.157			2.499	0.114
Rectum	542	432 (79.7)	45 (16.3)			263 (48.5)	279 (51.5)
Colon	484	368 (76.0)	49 (19.9)			211 (43.6)	273 (56.4)
Tumor size				4.988	0.026			33.175	0.000
< 5 cm	648	489 (75.5)	159 (24.5)			255 (39.4)	393 (60.6)
≥ 5 cm	378	308 (81.5)	70 (18.5)			219 (57.9)	159 (42.1)
Serosal invasion				11.130	0.001			10.697	0.001
No	266	188 (70.7)	78 (29.3)			100 (37.6)	166 (62.4)
Yes	760	612 (80.5)	148 (19.5)			374 (49.2)	386 (50.8)
Differentiation				6.553	0.038			6.911	0.032
Well	155	114 (73.5)	41 (26.5)			67 (43.2)	88 (56.8)
Moderate	589	476 (80.8)	113 (19.2)			258 (43.8)	331 (56.2)
Poor	282	210 (74.5)	72 (25.5)			149 (52.8)	133 (47.2)
Duke’s stage				15.191	0.000			62.045	0.000
A + B	491	357 (72.7)	134 (27.3)			164 (33.4)	327 (66.6)
C + D	535	443 (82.8)	92 (17.2)			310 (57.9)	225 (42.1)
Lymph node metastasis				14.865	0.000			40.430	0.000
Yes	595	506 (85.0)	89 (15.0)			325 (54.6)	270 (45.4)
No	431	294 (68.2)	137 (31.8)			149 (34.6)	282 (65.4)
Distal metastasis				3.928	0.047			3.901	0.048
Yes	141	119 (84.4)	22 (15.6)			76 (53.9)	65 (46.1)
No	885	681 (76.9)	204 (23.1)			398 (45.0)	487 (55.0)

Table 2 Relationship between COX-2 and HER-2 expression

COX-2 expression	HER-2 expression		Total	χ2	P value
	Positive	Negative
Positive	350	450	800	8.762	0.003
Negative	124	102	226
Total	474	552	1026