Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar

Table 1 Prevalence of Helicobacter pylori infection in each diagnostic test n (%)

	Age (yr)
	-29	30-39	40-49	50-59	60-	Total
n	43	65	56	55	33	252
Serum	16 (37.2)	27 (41.5)	21 (37.5)	21 (38.2)	8 (24.2)	93 (36.9)
RUT	9 (20.9)	33 (50.8)	17 (30.4)	21 (38.2)	6 (18.2)	86 (34.1)
Culture	9 (20.9)	26 (40.0)	18 (32.1)	18 (32.7)	3 (9.1)	74 (29.4)
Histology	11 (25.6)	29 (44.6)	20 (35.7)	23 (41.8)	7 (21.2)	90 (35.7)
IHC	11 (25.6)	29 (44.6)	20 (35.7)	23 (41.8)	7 (21.2)	90 (35.7)
Final	18 (41.9)	37 (56.9)	26 (46.4)	28 (50.9)	12 (36.4)	121 (48.0)

RUT: Rapid urease test; IHC: Immunohistochemistry.

Table 2 Differences of histological scores according to the status of Helicobacter pylori infection

	H. pylori (+)	H. pylori (-)	P value
n	121	131
Age	42.5 ± 13.1	44.7 ± 15.2	0.22
Male	50	47	0.37
PG I	86.9 ± 72.0	75.8 ± 77.0	0.006
PG II	17.3 ± 11.6	9.8 ± 10.4	< 0.001
PG I/II	5.3 ± 2.0	8.1 ± 2.6	< 0.001
PG-positive	8	4	0.18
Antrum
Activity	1.22 ± 0.82	0.08 ± 0.26	< 0.0001
Inflammation	1.53 ± 0.65	0.50 ± 0.54	< 0.0001
Atrophy	0.78 ± 0.52	0.39 ± 0.50	< 0.0001
Intestinal metaplasia	0.19 ± 0.59	0.05 ± 0.31	0.02
Corpus
Activity	0.74 ± 0.65	0.08 ± 0.29	< 0.0001
Inflammation	0.99 ± 0.63	0.15 ± 0.42	< 0.0001
Atrophy	0.25 ± 0.50	0.05 ± 0.25	< 0.0001
Intestinal metaplasia	0.04 ± 0.32	0.04 ± 0.28	0.72
OLGA score	0.84 ± 0.56	0.40 ± 0.52	< 0.0001

OLGA: Operative link on gastritis assessment; H. pylori: Helicobacter pylori; PG: Pepsinogen.

Table 3 Levels of PG I, PG II, and PG I/II in atrophic gastritis (mean ± SD)

	Grade	n	PG I	PG II	PG I/II
Antrum	0	114	76.2 ± 82.0	10.2 ± 10.2	7.7 ± 2.4
	1	131	85.1 ± 68.9	15.7 ± 12.0	6.0 ± 2.7
	2	7	87.7 ± 57.4	20.9 ± 14.6	4.9 ± 2.2
	3	0	NA	NA	NA
Corpus	0	220	82.3 ± 77.1	12.6 ± 11.4	7.1 ± 2.5
	1	27	65.4 ± 40.5	17.6 ± 9.6	4.0 ± 2.2
	2	5	114.0 ± 105.1	23.9 ± 22.0	4.5 ± 2.4
	3	0	NA	NA	NA
OLGA	0	109	77.2 ± 83.6	10.1 ± 10.3	7.8 ± 2.3
	I	132	82.6 ± 66.3	15.3 ± 11.2	6.0 ± 2.7
	II	10	104.8 ± 84.1	24.8 ± 17.7	4.1 ± 1.8
	III	1	67.8	8.7	7.8
	IV	0	NA	NA	NA

OLGA: Operative link on gastritis assessment; PG: Pepsinogen.