Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis

Table 1 Characteristics of colitis-associated colorectal cancer association analysis using 2 × 105 k in different groups of samples during the progression of ulcerative colitis with respect to copy number variations

	UC-LR	UC-HR	UC-PM	CAC
Total number of CNVs	178	271	616	958
Number of CNVs with gain	37	190	465	495
Number of CNVs with loss	141	81	151	463
Overall CNV coverage (in kb)	964.2	2368.5	4875	10540.1
Number of genes within CNVs	119	141	318	455

CNVs: Copy number variations; UC: Ulcerative colitis; CAC: Colitis-associated colorectal cancer; LR: Low risk; HR: High risk; PM: Premalignant.

Table 2 2 × 105 k CNV analysis of all the samples and gene list analysis using gene set enrichment analysis for functionally significant families of genes

	UC-LR	UC-HR	UC-PM	CAC
Cytokines and growth factors	0	0	2	2
Transcription factors	7	8	18	25
Cell differentiation markers	2	2	6	8
Protein kinases	7	8	9	8
Translocated cancer genes	1	4	5	11
Oncogenes	2	5	7	11
Tumor suppressor	0	0	0	1

UC: Ulcerative colitis; CAC: Colitis-associated colorectal cancer; LR: Low risk; HR: High risk; PM: Premalignant.