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©The Author(s) 2015.
World J Gastroenterol. Apr 21, 2015; 21(15): 4680-4687
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4680
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4680
Table 1 Histologic types and Human epidermal growth factor receptor 2 protein expression in mixed gastric carcinoma
Type | No. of cases | Immunohistochemistry | |||||
- | 1+ | 2+ | 3+ | Positive, n (%) | |||
Mixed adenocarcinoma | 216 | Extensive | 13 | 10 | 8 | 31 (14.4) | |
Partial | 21 | 15 | 14 | 50 (23.1) | |||
Focal | 7 | 5 | 3 | 15 (6.9) | |||
Negative | 120 | ||||||
Adenosquamous carcinoma | 34 | Extensive | 0 | 1 | 0 | 1 (2.9) | |
Partial | 2 | 2 | 1 | 5 (14.7) | |||
Focal | 2 | 0 | 1 | 3 (8.8) | |||
Negative | 25 | ||||||
Mixed adenocarcinoma and neuroendocrine carcinoma | 22 | Extensive | 0 | 0 | 0 | 0 (0.0) | |
Partial | 2 | 2 | 0 | 4 (18.2) | |||
Focal | 1 | 1 | 1 | 3 (13.6) | |||
Negative | 15 | ||||||
Mixed adenocarcinoma, squamous cell carcinoma and neuroendocrine carcinoma | 5 | Extensive | 0 | 0 | 0 | 0 (0.0) | |
Partial | 1 | 0 | 0 | 1 (20.0) | |||
Focal | 0 | 1 | 0 | 1 (20.0) | |||
Negative | 3 | ||||||
Total | 277 | 163 (58.8) | 49 (17.7) | 37 (13.4) | 28 (10.1) | 114 (41.2) |
Table 2 Human epidermal growth factor receptor 2 positive staining intensity and range distribution in mixed gastric carcinoma n (%)
Extensive | Partial | Focal | Value | |
Single-staining range | 10 | 23 | 9 | 42 (36.8) |
Multi-staining intensity | 22 | 37 | 13 | 72 (63.2) |
Total | 32 (11.6) | 60 (21.7) | 22 (7.9) | 114 (41.2) |
Table 3 Human epidermal growth factor receptor 2 protein expression and gene amplification results
Staining intensity (No. of cases) | HER2 protein expression | HER2 amplification | ||||
Staining Range | No. of cases | Cluster | Large granule | Dot | HH-17 | |
3+ (28) | Extensive | 8 | 3 | 2 | 2 | 1 |
Partial | 15 | 4 | 3 | 5 | 2 | |
Focal | 5 | 2 | 1 | 0 | 0 | |
2+ (37) | Extensive | 11 | 3 | 2 | 2 | 1 |
Partial | 19 | 3 | 2 | 1 | 1 | |
Focal | 7 | 1 | 1 | 0 | 0 | |
1+ (49) | Extensive | 13 | 1 | 1 | 0 | 1 |
Partial | 26 | 0 | 0 | 1 | 1 | |
Focal | 10 | 0 | 0 | 0 | 0 | |
Total | 114 | 17 | 12 | 11 | 7 |
Table 4 Human epidermal growth factor receptor 2 amplification status and survival analyses
Treatment | HER2 amplification | No. of cases | Survival analysis (mo) | |
Median PFS | Median OS | |||
Chemotherapy alone | Cluster | 7 | 6.3 | 11.9 |
Large granule | 6 | 5.8 | 12.2 | |
Dot | 4 | 5.3 | 11.6 | |
HH-17 | 2 | 5.1 | 12.7 | |
Trastuzumab combined with chemotherapy | Cluster | 9 | 10.7 | 18.1 |
Large granule | 6 | 9.9 | 17.7 | |
Dot | 5 | 8.3 | 16.5 | |
HH-17 | 2 | 7.6 | 14.3 |
Table 5 Summary of survival analyses
Treatment | No. of cases | Survival analysis | |||
Median PFS (mo) | P value | Median OS (mo) | P value | ||
Chemotherapy alone | 19 | 5.6 | 0.01 | 12.1 | 0.01 |
Trastuzumab combined with chemotherapy | 22 | 9.1 | 16.7 |
- Citation: Wang YK, Chen Z, Yun T, Li CY, Jiang B, Lv XX, Chu GH, Wang SN, Yan H, Shi LF. Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma. World J Gastroenterol 2015; 21(15): 4680-4687
- URL: https://www.wjgnet.com/1007-9327/full/v21/i15/4680.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i15.4680