Copyright
©The Author(s) 2015.
World J Gastroenterol. Apr 21, 2015; 21(15): 4599-4606
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4599
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4599
Table 1 Baseline patient characteristics n (%)
Characteristics | Value |
Age, median (range), yr | 50 (20-87) |
Gender | |
Male | 150 (50) |
Female | 150 (50) |
Symptoms | |
Abdominal burn | 152 (50.70) |
Heart burn | 37 (12.30) |
Dyspepsia | 33 (11) |
Past medical history | |
Hypertension | 81 (27) |
Dyslipidemia | 53 (17.7) |
Diabetes mellitus | 36 (12) |
Hypothyroidism | 9 (3) |
Social habits | |
Smoking | 126 (42) |
Exercise | 98 (32.7) |
Alcohol intake | 62 (20.7) |
Medication history | |
Anti hypertensives | 86 (28.7) |
Anti dyslipidemics | 54 (18) |
Oral hypoglycemics | 28 (9.3) |
Sedatives | 15 (5) |
Anti-depressants | 16 (5.3) |
PPIs1 | 155 (51.7) |
Indications for PPI use | |
Gastritis | 21 (13.5) |
GERD | 48 (31) |
GI ulcer | 10 (6.5) |
Undocumented diagnosis | 76 (49) |
Table 2 Effect of proton pump inhibitors exposure on Helicobacter pylori detection, density and intestinal metaplasia n (%)
Previous PPI exposuren = 155 | No PPI exposuren = 145 | P value | |
H. pylori gastritis | 53 (34.20) | 103 (71) | < 0.001 |
Inactive chronic gastritis | 102 (65.80) | 42 (29) | < 0.001 |
H. pylori density | |||
Low density | 40 (25.80) | 52 (35.90) | < 0.001 |
High density | 13 (8.38) | 51 (35.17) | < 0.001 |
Intestinal metaplasia | 10 (6.50) | 2 (1.40) | 0.023 |
Table 3 Effect of proton pump inhibitors exposure on Helicobacter pylori detection, density and intestinal metaplasia following gastroesophageal reflux disease patients exclusion n (%)
Previous PPI exposuren = 109 | No PPI exposuren =143 | P value | |
Gastritis | |||
H. pylori gastritis | 44 (40.40) | 101 (70.60) | |
Inactive chronic gastritis | 65 (59.60) | 42 (29.40) | < 0.0001 |
H. pylori density | |||
Low density | 33 (75.0) | 52 (51.50) | |
High density | 11 (25.0) | 49 (48.50) | 0.010 |
Intestinal metaplasia | 7 (6.40) | 2 (1.40) | 0.042 |
Table 4 Univariate analysis to determine the association between age, gender, exercise, smoking, alcohol intake, gastroesophageal reflux disease and previous proton pump inhibitors exposure with the detection of Helicobacter pylori
OR | 95%CI | P value | |
Age | 1.019 | 1.002-1.036 | 0.028 |
Gender | 1.256 | 0.76-2.07 | 0.373 |
Exercise | 0.664 | 0.389-1.136 | 0.135 |
Smoking | 0.789 | 0.476-1.308 | 0.358 |
Alcohol intake | 0.505 | 0.27-0.944 | 0.032 |
GERD | 0.165 | 0.077-0.355 | < 0.01 |
Previous PPI exposure | 0.281 | 0.166-0.476 | < 0.01 |
Table 5 Multivariate analysis to evaluate the effect of age, exercise, alcohol intake, gastroesophageal reflux disease and previous proton pump inhibitors exposure on the detection of Helicobacter pylori
OR | 95%CI | P value | |
Age | 1.022 | 1.004-1.041 | 0.017 |
Alcohol intake | 0.396 | 0.195-0.804 | 0.010 |
Exercise | 0.721 | 0.393-1.321 | 0.289 |
GERD | 0.317 | 0.132-0.763 | 0.010 |
Previous PPI exposure | 0.217 | 0.123-0.385 | < 0.01 |
- Citation: Nasser SC, Slim M, Nassif JG, Nasser SM. Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes. World J Gastroenterol 2015; 21(15): 4599-4606
- URL: https://www.wjgnet.com/1007-9327/full/v21/i15/4599.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i15.4599