Contrast-enhanced ultrasound for quantitative assessment of portal pressure in canine liver fibrosis

Table 1 Pathologic staging of liver biopsies from the canine model

Stage	8th wk	16th wk	24th wk	Total
F0	3	0	0	3
F1	9	3	0	12
F2	2	8	4	14
F3	0	3	8	11
F4	0	0	2	2
Total	14	14	14	42

Table 2 Free portal pressure and contrast-enhanced ultrasound parameters in normal and treated canines (n = 14)

Time in weeks	FPP in cm H2O	Qp/Qa	Ip/Ia
Normal	10.26 ± 2.12	19.85 ± 3.30	1.77 ± 0.37
8	18.31 ± 3.17	11.32 ± 0.92	1.04 ± 0.12
16	28.20 ± 2.57	9.43 ± 0.85	0.85 ± 0.07
24	36.30 ± 2.21	7.27 ± 0.81	0.66 ± 0.13
P	< 0.001	< 0.001	< 0.001

Ip/Ia: Intensity of the portal venous phase/hepatic arterial phase; Qp/Qa: Area under the curve of the portal venous phase/hepatic arterial phase. FPP: Free portal pressure.