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©The Author(s) 2015.
World J Gastroenterol. Apr 14, 2015; 21(14): 4365-4372
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4365
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4365
Table 1 Characteristics of included studies
Ref. | Year | Patients assessed | KRAS wt | KRAS mut | Response criteria |
1st line treatment | |||||
Maughan et al[11] | 2011 | 1630 | 729 | 565 | RECIST |
Van Cutsem et al[12] | 2011 | 1198 | 666 | 397 | WHO |
Bokemeyer et al[7] | 2011 | 337 | 179 | 136 | WHO |
Douillard et al[13] | 2010 | 1183 | 656 | 440 | RECIST |
Hecht et al[14] | 2009 | 823 | 404 | 260 | RECIST |
Hecht et al[14] | 2009 | 230 | 115 | 86 | RECIST |
Tol et al[15] | 2009 | 755 | 314 | 206 | RECIST |
Tveit et al[16] | 2012 | 566 | 303 | 195 | RECIST |
2nd line treatment | |||||
Peeters et al[17] | 2010 | 1186 | 597 | 486 | RECIST |
Harbison et al[18] | 2012 | 572 | 245 | 208 | RECIST |
Amado et al[19] | 2008 | 463 | 243 | 184 | RECIST |
Table 2 Treatment protocols in included studies
Ref. | Study treatment protocol |
1st line treatment | |
Maughan et al[11] | Ox 85 mg/m2 FA 350 mg/m2 5FU 400 mg/m2 bolus + 2400 mg/m2 infusion ± cetuximab |
Ox 130 mg/m2 Cap 2000 mg/m2± cetuximab | |
Van Cutsem et al[12] | Iri 180 mg/m2 FA 400 mg/m2 5FU 400 mg/m2 bolus + 2400 mg/m2 infusion ± cetuximab |
Bokemeyer et al[7] | Ox 85 mg/m2 FA 400 mg/m2 5FU 400 mg/m2 bolus + 1200 mg/m2 infusion ± cetuximab |
Douillard et al[13] | Ox 85 mg/m2 FA 400 mg/m2 5FU 400 mg/m2 bolus + 1200 mg/m2 infusion ± panitumumab |
Hecht et al[14] | Ox/FA/5FU/Bev |
Hecht et al[14] | Iri/FA/5FU/Bev |
Tol et al[15] | Ox/Cap/Bev |
Tveit et al[16] | Ox 85 mg/m2 FA 120 mg/m2 5FU 1000 mg/m2 bolus ± cetuximab |
2nd line treatment | |
Peeters et al[17] | Iri 180 mg/m2 FA 400 mg/m2 5FU 400 mg/m2 bolus + 2400 mg/m2 infusion ± panitumumab |
Harbison et al[18] | BSC ± cetuximab |
Amado et al[19] | BSC ± panitumumab |
- Citation: Song QB, Wang Q, Hu WG. Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis. World J Gastroenterol 2015; 21(14): 4365-4372
- URL: https://www.wjgnet.com/1007-9327/full/v21/i14/4365.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i14.4365