Copyright
©The Author(s) 2015.
World J Gastroenterol. Apr 14, 2015; 21(14): 4268-4274
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4268
Published online Apr 14, 2015. doi: 10.3748/wjg.v21.i14.4268
Table 1 Patient characteristics n (%)
Characteristics | Patients |
Total number of patients | 33 |
Age (yr), median (range) | 59 (44-76) |
Gender | |
Male | 31 (94) |
Female | 2 (6) |
ECOG PS | |
1 | 32 (97) |
2 | 1 (3) |
Anatomic site | |
Upper thoracic | 1 (3) |
Middle thoracic | 26 (79) |
Distal | 6 (18) |
Prior curative-aim treatment | |
None | 7 (21) |
Surgery | 23 (70) |
Chemoradiotherapy | 3 (9) |
Number of prior chemotherapy regimens | |
1 | 25 (76) |
2 | 8 (24) |
Tumor grade | |
Well differentiated | 3 (9) |
Moderately differentiated | 18 (55) |
Poorly differentiated or unknown | 12 (36) |
Metastatic site (s) | |
Lymph node | 29 (88) |
Lung | 14 (42) |
Liver | 6 (18) |
Bone | 3 (9) |
Table 2 Toxicity profile per patient (n = 33): Worst grade reported during the treatment period n (%)
NCI-CTC grade | ||||||
1 | 2 | 3 | 4 | 1-4 | 3/4 | |
Hematologic | ||||||
Anemia | 13 | 16 | 3 | 0 | 32 (97) | 3 (9) |
Neutropenia | 0 | 5 | 10 | 3 | 18 (55) | 13 (39) |
Thrombocytopenia | 6 | 2 | 1 | 1 | 10 (30) | 2 (6) |
Febrile neutropenia | 0 | 0 | 3 | 0 | 3 (9) | 3 (9) |
Non-hematologic | ||||||
Asthenia/Fatigue | 13 | 4 | 4 | 0 | 21 (64) | 4 (12) |
Myalgia | 5 | 1 | 0 | 0 | 6 (18) | 0 (0) |
Anorexia | 10 | 2 | 1 | 0 | 13 (39) | 1 (3) |
Nausea | 5 | 1 | 1 | 0 | 7 (21) | 1 (3) |
Vomiting | 4 | 0 | 1 | 0 | 5 (15) | 1 (3) |
Mucositis/Stomatitis | 6 | 2 | 0 | 0 | 8 (24) | 0 (0) |
Diarrhea | 6 | 2 | 0 | 0 | 8 (24) | 0 (0) |
Hand-foot syndrome | 2 | 2 | 0 | 0 | 4 (12) | 0 (0) |
Peripheral neuropathy | 6 | 0 | 0 | 0 | 6 (18) | 0 (0) |
Alopecia | 14 | 1 | 0 | 0 | 15 (46) | 0 (0) |
Headache | 5 | 0 | 0 | 0 | 5 (15) | 0 (0) |
Dysphagia | 7 | 1 | 0 | 0 | 8 (24) | 0 (0) |
Rash | 4 | 2 | 0 | 0 | 6 (18) | 0 (0) |
Cough | 4 | 1 | 1 | 0 | 6 (18) | 1 (3) |
Sputum | 7 | 1 | 1 | 0 | 9 (27) | 1 (3) |
Chest discomfort | 10 | 0 | 0 | 0 | 10 (30) | 0 (0) |
- Citation: Lee MY, Jung KS, Kim HS, Lee JY, Lim SH, Kim M, Jung HA, Kim SM, Sun JM, Ahn MJ, Lee J, Park SH, Yi SY, Hwang IG, Lee SC, Ahn HK, Lim DH, Lee SI, Park KW. Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma. World J Gastroenterol 2015; 21(14): 4268-4274
- URL: https://www.wjgnet.com/1007-9327/full/v21/i14/4268.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i14.4268