Copyright
©The Author(s) 2015.
World J Gastroenterol. Apr 7, 2015; 21(13): 4006-4013
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.4006
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.4006
Table 1 Primer and probe of SNPs
SNPs | Primer and probe (5’-3’) | |
rs10903035 | Forward primer | TTGCCACCCTTGACCTCAG |
Reverse primer | GAGGTTTTGTTTAGAGGGATCCAC | |
Probe-FAM | TAGCAAACCACTCCTT | |
Probe-HEX | TTAGCAAATCACTCCTT | |
rs11249006 | Forward primer | AACTGGAAGGGAGAATGGGACT |
Reverse primer | GTAACATGGCAGGAATCGGACT | |
Probe-FAM | CCACAACAGTCAACCA | |
Probe-HEX | CACAACGGTCAACCA | |
rs2834167 | Forward primer | TACCACCTCCCGAAAATGTCA |
Reverse primer | GGTGCGTTCCTGCCAATAGT | |
Probe-FAM | TTCCCTTTGGCAAAAG | |
Probe-HEX | TTCCCTTCGGCAAAA | |
rs2071430 | Forward primer | CCGAGAACCTGCGTCTCC |
Reverse primer | CGCGAAGAAATGAAACTCACAGAC | |
Probe-FAM | CGTTTCTGCGCCCG | |
Probe-HEX | CGTTTCTGCTCCCG | |
rs17000900 | Forward primer | CCGAGAACCTGCGTCTCC |
Reverse primer | CGCGAAGAAATGAAACTCACAGAC | |
Probe-FAM | CAAGTGCTGCAGGTG | |
Probe-HEX | CAAGTGCTGAAGGTG | |
rs12980275 | Forward primer | TGAGGTGCTGAGAGAAGTCAAATT |
Reverse primer | CGCTACCCCGGCAAATATT | |
Probe-FAM | CTAGAAACGGACGTGTC | |
Probe-HEX | CTAGAAACAGACGTGTCT |
Table 2 Baseline characteristics of participants n (%)
Variables | RVR(n = 133) | NRVR(n = 105) | P value |
Age (yr) | |||
≤ 50 | 51 (38.35) | 40 (38.10) | |
> 50 | 82 (61.65) | 65 (61.90) | 0.968 |
Sex | |||
Male | 41 (30.83) | 21 (20.00) | |
Female | 92 (69.17) | 84 (80.00) | 0.059 |
HCV genotype | |||
1a/1b | 93 (69.92) | 70 (66.67) | |
3 | 14 (10.53) | 5 (4.76) | |
Mixed | 26 (19.55) | 30 (28.57) | 0.102 |
ALT (U/L) | |||
≤ 40 | 64 (48.12) | 28 (26.67) | |
(40-80] | 38 (28.57) | 42 (40.00) | |
> 80 | 30 (22.56) | 35 (33.33) | 0.003 |
ALB (g/L) | |||
[40-55] | 99 (74.44) | 82 (78.10) | |
< 40 | 33 (24.81) | 23 (21.90) | 0.577 |
WBC (× 109/L) | |||
[4-10] | 75 (56.39) | 73 (69.52) | |
< 4 | 57 (42.86) | 31 (29.52) | 0.035 |
> 10 | 1 (0.75) | 1 (0.95) | 0.985 |
PLT (× 109/L) | |||
[100-300] | 90 (67.67) | 68 (64.76) | |
< 100 | 41 (30.83) | 37 (35.24) | 0.522 |
AFP (ng/mL) | |||
≤ 7 | 95 (71.43) | 68 (64.76) | |
> 7 | 19 (14.29) | 30 (28.57) | 0.016 |
HGB (g/L) | |||
[110-150] | 99 (74.44) | 89 (84.76) | |
< 110 | 13 (9.77) | 8 (7.62) | |
> 150 | 21 (15.79) | 8 (7.62) | 0.116 |
Baseline RNA (lg, IU/mL) | 6.02 ± 0.97 | 6.19 ± 0.74 | 0.138 |
Table 3 Interferon-λ-related genes polymorphisms and rapid viral response n (%)
Genotype | RVR | NRVR | Crude OR (95%CI) | Adjusted OR (95%CI) |
rs11249006 | n = 133 | n = 105 | ||
AA | 51 (38.35) | 49 (46.67) | 1 | 1 |
AG | 62 (46.62) | 49 (46.67) | 1.22 (0.71-2.09) | 0.86 (0.45-1.63) |
GG | 20 (15.04) | 7 (6.67) | 2.75 (1.07-7.07) | 2.33 (0.84-6.48) |
Dominant | 1.41 (0.84-2.36) | 1.06 (0.58-1.94) | ||
Recessive | 2.48 (1.01-6.11) | 2.52 (0.96-6.64) | ||
Additive | 1.47 (0.99-2.19) | 1.27 (0.82-1.98) | ||
rs12980275 | n = 133 | n = 105 | ||
AA | 118 (88.72) | 70 (66.67) | 1 | 1 |
AG | 8 (6.02) | 28 (26.67) | 0.17 (0.07-0.39) | 0.11 (0.04-0.30) |
GG | 7 (5.26) | 7 (6.67) | 0.59 (0.20-1.76) | 0.54 (0.17-1.74) |
Dominant | 0.25 (0.13-0.50) | 0.19 (0.09-0.43) | ||
Recessive | 0.78 (0.26-2.29) | 0.82 (0.26-2.56) | ||
Additive | 0.46 (0.28-0.76) | 0.43 (0.24-0.75) | ||
rs2834167 | n = 133 | n = 105 | ||
AA | 37 (27.82) | 28 (26.67) | 1 | 1 |
AG | 79 (59.40) | 62 (59.05) | 0.96 (0.53-1.74) | 0.90 (0.45-1.78) |
GG | 17 (12.78) | 15 (14.29) | 0.86 (0.37-2.01) | 0.66 (0.23-1.88) |
Dominant | 0.94 (0.53-1.68) | 0.85 (0.44-1.66) | ||
Recessive | 0.88 (0.42-1.86) | 0.71 (0.28-1.83) | ||
Additive | 0.93 (0.62-1.41) | 0.83 (0.51-1.36) | ||
rs10903035 | n = 133 | n = 105 | ||
AA | 43 (32.33) | 27 (25.71) | 1 | 1 |
AG | 56 (42.11) | 48 (45.71) | 0.73 (0.40-1.36) | 0.68 (0.34-1.37) |
GG | 34 (32.28) | 30 (28.57) | 0.71 (0.36-1.42) | 0.91 (0.41-2.02) |
Dominant | 0.72 (0.41-1.28) | 0.76 (0.40-1.44) | ||
Recessive | 0.86 (0.48-1.53) | 1.14 (0.58-2.25) | ||
Additive | 0.84 (0.60-1.19) | 0.94 (0.63-1.40) | ||
rs2071430 | n = 127 | n = 96 | ||
GG | 63 (49.61) | 49 (51.04) | 1 | 1 |
GT | 49 (38.58) | 40 (41.67) | 0.95 (0.54-1.67) | 0.94 (0.50-1.80) |
TT | 15 (11.81) | 7 (7.29) | 1.67 (0.63-4.40) | 2.13 (0.66-6.85) |
Dominant | 1.14 (0.68-1.91) | 1.26 (0.70-2.28) | ||
Recessive | 1.78 (0.70-4.54) | 2.28 (0.73-7.08) | ||
Additive | 1.15 (0.77-1.72) | 1.21 (0.76-1.94) | ||
rs17000900 | n = 130 | n = 99 | ||
AA | 97 (74.62) | 69 (69.70) | 1 | 1 |
AG | 29 (22.31) | 27 (27.27) | 0.76 (0.42-1.40) | 0.79 (0.39-1.61) |
GG | 4 (3.08) | 3 (3.03) | 0.95 (0.21-4.38) | 0.68 (0.13-3.70) |
Dominant | 0.83 (0.46-1.47) | 0.83 (0.43-1.62) | ||
Recessive | 1.05 (0.23-4.82) | 0.77 (0.14-4.16) | ||
Additive | 0.84 (0.51-1.38) | 0.80 (0.45-1.42) |
Table 4 Polymorphisms of IL28RA/IL28B and rapid viral response n (%)
Genotype | RVR (n = 133) | NRVR (n = 105) | Crude OR (95%CI) | P value | Adjusted OR (95%CI) | P value |
rs11249006 | ||||||
AA | 51 (38.35) | 49 (46.67) | 1 | 1 | ||
AG | 62 (46.62) | 49 (46.67) | 1.22 (0.71-2.09) | 0.048 | 0.86 (0.45-1.63) | 0.637 |
GG | 20 (15.04) | 7 (6.67) | 2.75 (1.07-7.07) | 0.036 | 2.33 (0.84-6.48) | 0.104 |
Dominant | 1.41 (0.84-2.36) | 0.197 | 1.06 (0.58-1.94) | 0.852 | ||
Recessive | 2.48 (1.01-6.11) | 0.049 | 2.52 (0.96-6.64) | 0.061 | ||
Additive | 1.47 (0.99-2.19) | 0.055 | 1.27 (0.82-1.98) | 0.282 | ||
rs12980275 | ||||||
AA | 118 (88.72) | 70 (66.67) | 1 | 1 | ||
AG | 8 (6.02) | 28 (26.67) | 0.17 (0.07-0.39) | < 0.001 | 0.11 (0.04-0.30) | < 0.001 |
GG | 7 (5.26) | 7 (6.67) | 0.59 (0.20-1.76) | 0.347 | 0.54 (0.17-1.74) | 0.301 |
Dominant | 0.25 (0.13-0.50) | < 0.001 | 0.19 (0.09-0.43) | < 0.001 | ||
Recessive | 0.78 (0.26-2.29) | 0.648 | 0.82 (0.26-2.56) | 0.736 | ||
Additive | 0.46 (0.28-0.76) | 0.002 | 0.43 (0.24-0.75) | 0.003 |
Table 5 Results of multivariate stepwise regression analysis on rapid viral response
Variable | Coef | OR (95%CI) | P value |
rs12980275 | -1.05 | 0.35 (0.20-0.62) | < 0.001 |
WBC-group | 0.67 | 1.94 (1.08-3.50) | 0.027 |
AFP-group | -0.98 | 0.38 (0.19-0.76) | 0.006 |
HCV genotype | -0.39 | 0.67 (0.48-0.96) | 0.014 |
Baseline RNA(lg) | -0.46 | 0.63 (0.44-0.91) | 0.027 |
- Citation: Zhang YY, Chen HB, Xu Y, Huang P, Wang J, Zhang Y, Yu RB, Su J. Interferon-λ-related genes and therapeutic response in Chinese hepatitis C patients. World J Gastroenterol 2015; 21(13): 4006-4013
- URL: https://www.wjgnet.com/1007-9327/full/v21/i13/4006.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i13.4006