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©The Author(s) 2015.
World J Gastroenterol. Apr 7, 2015; 21(13): 3936-3943
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3936
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3936
Table 1 Baseline demographic and clinical characteristics of patients and univariate analysis of clinical factors influencing the eradication rate n (%)
Eradication success(n = 290) | Eradication failure(n = 36) | P value | Univariate analysis | |
Age | 56.7 ± 10.4 | 56.9 ± 10.7 | 0.124 | 0.127 |
Gender | 0.229 | 0.233 | ||
Male | 183 (63.1) | 19 (52.7) | ||
Female | 107 (36.9) | 17 (47.3) | ||
Smoking | 0.789 | 0.792 | ||
Non-smoker | 228 (78.6) | 29 (80.5) | ||
Smoker | 62 (21.4) | 7 (19.5) | ||
Alcohol | 0.213 | 0.219 | ||
Non-drinker | 224 (77.2) | 23 (63.8) | ||
Drinker | 66 (22.8) | 13 (36.2) | ||
Underlying disease | ||||
Hypertension | 65 (22.4) | 6 (16.6) | 0.431 | 0.437 |
Diabetes mellitus | 24 (8.2) | 4 (11.1) | 0.531 | 0.539 |
EGC/AGC | 0.451 | 0.463 | ||
EGC | 217 (74.8) | 29 (80.5) | ||
AGC | 73 (25.2) | 7 (19.5) | ||
Tumor location | 0.695 | 0.707 | ||
Lower (Antrum) | 147 (50.6) | 17 (47.2) | ||
Middle (Body) | 143 (49.3) | 19 (52.7) | ||
Surgery | 0.012 | 0.016 | ||
Billroth-I | 201 (69.4) | 33 (91.7) | ||
Billroth-II | 89 (30.6) | 3 (8.3) |
Table 2 H. pylori eradication rates of first- and second-line therapy
First-line therapy | Second-line therapy | P value | |
ITT analysis | |||
%, Eradication(ratio) | 78.4 (458/584) | 90 (36/40) | 0.027 |
95%CI | 74.9-81.6 | 77.0-96.0 | |
PP analysis | |||
%, Eradication(ratio) | 85.3 (458/530) | 92.3 (36/39) | 0.034 |
95%CI | 82.1-88.1 | 79.7-97.4 |
Table 3 Multivariate analysis for the clinical factors related to the eradication success in the eradication success group
Odds ratio | 95%CI | P value | |
Billroth-II vs Billroth-I | 1.53 | 1.41-1.65 | 0.021 |
Male vs female | 1.01 | 0.87-1.15 | 0.125 |
Smoking (+) vs (-) | 1.07 | 0.89-1.25 | 0.163 |
Alcohol (+) vs (-) | 0.98 | 0.94-1.08 | 0.187 |
Table 4 Histological changes of gastric mucosa according to eradication
Eradication success (n = 290) | Eradication failure (n = 36) | P value | |||||
Baseline | 12 mo | P value | Baseline | 12 mo | P value | ||
Atrophy | 0.46 ± 0.04 | 0.25 ± 0.04 | < 0.001 | 0.50 ± 0.11 | 0.47 ± 0.12 | 0.698 | 0.023 |
IM | 0.41 ± 0.05 | 0.27 ± 0.04 | < 0.001 | 0.56 ± 0.14 | 0.51 ± 0.12 | 0.226 | 0.015 |
Neutrophil count | 2.12 ± 0.04 | 0.40 ± 0.04 | < 0.001 | 2.08 ± 0.12 | 1.11 ± 0.18 | < 0.001 | < 0.001 |
Mononuclear cells | 2.10 ± 0.03 | 1.45 ± 0.03 | < 0.001 | 2.08 ± 0.08 | 1.64 ± 0.11 | 0.004 | 0.085 |
Table 5 Comparison of histological changes of gastric mucosa in metachronous cancer patients (n = 7)
Baseline | 12 mo | P value | |
Atrophy | 1.29 ± 0.42 | 0.71 ± 0.36 | 0.436 |
Intestinal metaplasia | 1.34 ± 0.41 | 1.00 ± 0.38 | 0.457 |
Neutrophil count | 2.00 ± 0.22 | 0.86 ± 0.34 | 0.071 |
Mononuclear cell | 2.00 ± 0.31 | 1.85 ± 0.20 | 0.289 |
Table 6 Histological changes of gastric mucosa according to reconstruction surgery after successful eradication
Billroth-I (n = 201) | Billroth-II (n = 89) | P value | |||||
Baseline | 12 mo | P value | Baseline | 12 mo | P value | ||
Atrophy | 0.33 ± 0.10 | 0.31 ± 0.12 | 0.831 | 0.53 ± 0.19 | 0.13 ± 0.09 | < 0.001 | 0.029 |
IM | 0.39 ± 0.13 | 0.37 ± 0.13 | 0.572 | 0.67 ± 0.21 | 0.32 ± 0.24 | < 0.001 | 0.034 |
Neutrophil count | 2.24 ± 0.10 | 0.21 ± 0.08 | < 0.001 | 2.33 ± 0.16 | 0.33 ± 0.16 | < 0.001 | < 0.001 |
Mononuclear cells | 2.21 ± 0.10 | 1.33 ± 0.12 | 0.831 | 1.93 ± 0.19 | 1.47 ± 0.09 | 0.540 | 0.085 |
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Citation: Hwang JJ, Lee DH, Kang KK, Lee AR, Yoon H, Shin CM, Park YS, Kim N. Eradication rate and histological changes after
Helicobacter pylori eradication treatment in gastric cancer patients following subtotal gastrectomy. World J Gastroenterol 2015; 21(13): 3936-3943 - URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3936.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3936