To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases

Table 1 Summary of the gene and their locus studied with respect to Helicobacter pylori mediated gastro-duodenal disease

Gene	Locus/polymorphism	Susceptible/protection	Population/ethnicity	Disease	Ref.
IL1B	C>T -511, C>T -31, C>T +3954	Susceptible	Scottish, Polish, American, Portugese, Japanese and Mexican	Gastric cancer	di Giovine et al, 1992; Stokkers et al, 1998; El omar et al, 2000; El omar et al, 2003; Machado et al, 2001; Furuta et al, 2002; Garza-Gonzalez et al, 2003
	C>T -511/-31T>C	Susceptible	Indian, American, Japanese, Chinese	Duodenal ulcer	Charkarvorty et al, 2006; Kato et al, 2001; Lee et al, 2003; Furuta et al, 2002
ILRN	86bp VNTR/ intron 2	Susceptible	Indian, American, Japanese, Chinese	Gastric cancer	Tarlow et al, 1993
TNFα	G/G-308	Susceptible	Indian, American, Japanese, Chinese	Duodenal ulcer	Kuntsmann et al, 1999
	A/A-308	Susceptible	American, Japanese, Chinese	Gastric cancer	El Omar et al, 2003
	T/T-857	Susceptible	American, Japanese, Chinese	Duodenal ulcer/gastric ulcer	Zambon et al, 2005
	T/T-1031	Susceptible	American, Japanese, Chinese	Antral inflamation	Zambon et al, 2005
	A/A -238	Protective	American, Japanese, Chinese	Gastric cancer	Jang et al, 2001
IL6	G/G-174	Susceptible	American, Japanese, Chinese	Gastritis	Lobbo gatti, 2005
IL8	A/A-251	Susceptible	Chinese, Venezuelan	Gastric cardia carcinogenesis, Dysplasia	Savage et al, 2004; Kato et al, 2006
	G/G + 396	Susceptible	Chinese	Gastric cardia carcinogenesis	Savage et al, 2005
IL-10	ATA-592/-819/-1082	Susceptible		Noncardia gastric cancer	Rad et al, 2010
XPD	rs1318 (lys751Gln)	Susceptible	Guangxi population, Chinese	GAA	Long et al, 2010
XRCC4	rs1805377 (ser298Asn)	Susceptible	Chinese	GAA	Long et al, 2010
HLA class II	DQB1*0301	Susceptible		GAA	Lee et al
HLA	DQA1*0102	Protective		Gastric atrophy and Intestinal GAA	Azuma et al, magunson et al
class II
HLA class II	DRB1*1601	Susceptible		GAA	Magnusson et al
cox-2	G>A, -899 GC+CC	Susceptible	Hexi area of Gansu province, Chinese	GAA	Ke-Xiang et al
TLR-1, TLR-2, TLR-4		Suceptibilty	Cohorts in Germany and Netherlands	H. pylori infection	Mayerle et al, 2013
TLR-4	A>G-896	Susceptible	Caucasian	Increased inflamatory response, Hypochlorhydria	Arbor et al, 2000; Hold et al, 2009; El omar, 2003
Bmp6		Susceptible	Caucasian	Gastric cancer	Katoh et al, 2006
Gdf15		Susceptible	Caucasian	Gastric cancer	Katoh et al, 2006
Runx3		Susceptible	Caucasian	Gastric cancer	Kaoh et al, 2006
Cdh1		Susceptible	Caucasian	Gastric cancer	Guilford et al, 1998

IL: Interleukin 1 beta; TNF: Tumor necrosis factor; H. pylori: Helicobacter pylori.