Intestinal stem cells and the colorectal cancer microenvironment

doi:10.3748/wjg.v20.i8.1898

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Feb 28, 2014 (publication date) through Dec 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2014; 20(8): 1898-1909
Published online Feb 28, 2014. doi: 10.3748/wjg.v20.i8.1898

Table 1 Putative colorectal cancer stem cell markers

Marker	Function
ALDH1A1	Enzyme
ALDH1B1	Enzyme
β-catenin	Protein (nuclear)
Bmi-1	Protein (nuclear)
CD24	Cell surface glycoprotein
CD26	Cell surface glycoprotein
CD29	Cell surface glycoprotein
CD44	Cell surface glycoprotein
CD133	Cell surface glycoprotein
CD166 (ALCAM)	Cell surface glycoprotein
CDX-2	Transcription factor
c-myc	Transcription factor
Dclk-1	Serine-threonine kinase (?)
EpCAM	Cell surface glycoprotein
Klf-4	Transcription factor
Lgr-5	Cell surface receptor
Lin-28	Transcription factor
Msi-1	Protein (nuclear)
Nanog	Transcription factor
4-Oct	Transcription factor
Sox-2	Transcription factor

ALDH: Aldehyde dehydrogenase; Bmi-1: B lymphoma Mo-MLV insertion region 1 homolog; CD: Cluster of differentiation; CDX-2: Caudal type homeobox 2; Dclk-1: Doublecortin-like kinase-1; EpCAM: Epithelial cell adhesion molecule; Lgr-5: Leucine-rich repeat-containing G protein coupled receptor 5; Msi-1: Musashi-1.

Citation: Ong BA, Vega KJ, Houchen CW. Intestinal stem cells and the colorectal cancer microenvironment. World J Gastroenterol 2014; 20(8): 1898-1909
URL: https://www.wjgnet.com/1007-9327/full/v20/i8/1898.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i8.1898